Trial reportClinical interventions in aging2008
Can HMG Co-A reductase inhibitors ("statins") slow the progression of age-related macular degeneration? The age-related maculopathy statin study (ARMSS).
Trial report in Clinical interventions in aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Statins for age-related macular degeneration.The Cochrane database of systematic reviews · 2016Pooled it
- Statins for age-related macular degeneration.The Cochrane database of systematic reviews · 2015Pooled it
- Statins for age-related macular degeneration.The Cochrane database of systematic reviews · 2012Pooled it
- Statins for age-related macular degeneration.The Cochrane database of systematic reviews · 2009Pooled it
- Proof of concept, randomized, placebo-controlled study of the effect of simvastatin on the course of age-related macular degeneration.PloS one · 2013Trial
- Article
- The Question of a Role for Statins in Age-Related Macular Degeneration.International journal of molecular sciences · 2018Review
- Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors.Eye and vision (London, England) · 2016Review
- Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008.Eye (London, England) · 2014Article
- Do statins have a role in the prevention of age-related macular degeneration?Drugs & aging · 2013Review
- The controversy over the association between statins use and progression of age-related macular degeneration: a mini review.Clinical ophthalmology (Auckland, N.Z.) · 2010Article
- Eye on statins: A comprehensive review.Missouri medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related macular degeneration (AMD) is responsible for the majority of visual impairment in the Western world. The role of cholesterol-lowering medications, HMG Co-A reductase inhibitors or statins, in reducing the risk of AMD or of delaying its progression has not been fully investigated. A 3-year prospective randomized controlled trial of 40 mg simvastatin per day compared to placebo in subjects at high risk of AMD progression is described. This paper outlines the primary aims of the Age-Related Maculopathy Statin Study (ARMSS), and the methodology involved. Standardized clinical grading of macular photographs and comparison of serial macular digital photographs, using the International grading scheme, form the basis for assessment of primary study outcomes. In addition, macular function is assessed at each visit with detailed psychophysical measurements of rod and cone function. Information collected in this study will assist in the assessment of the potential value of HMG Co-A reductase inhibitors (statins) in reducing the risk of AMD progression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.