ArticleAnnals of biomedical engineering2009
Bimodal analysis of mammary epithelial cell migration in two dimensions.
Article in Annals of biomedical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- pERK transition-induced directional mode switching promotes epithelial tumor cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Changes in cell surface excess are coordinated with protrusion dynamics during 3D motility.Biophysical journal · 2023Article
- Exact solution for the Anisotropic Ornstein-Uhlenbeck process.Physica A · 2022Article
- Topological data analysis of collective and individual epithelial cells using persistent homology of loops.Soft matter · 2021Article
- CompuCell3D Simulations Reproduce Mesenchymal Cell Migration on Flat Substrates.Biophysical journal · 2020Article
- Steering cell migration by alternating blebs and actin-rich protrusions.BMC biology · 2016Article
- Quantifying and predicting Drosophila larvae crawling phenotypes.Scientific reports · 2016Article
- Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells.Nature · 2012Article
- In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.Biophysical journal · 2011Article
- Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.Biophysical journal · 2010Article
- Collective chemotaxis requires contact-dependent cell polarity.Developmental cell · 2010Article
- Article
- An off-lattice hybrid discrete-continuum model of tumor growth and invasion.Biophysical journal · 2010Article
- Microenvironmental independence associated with tumor progression.Cancer research · 2009Article
- Trait variability of cancer cells quantified by high-content automated microscopy of single cells.Methods in enzymology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cell migration paths of mammary epithelial cells (expressing different versions of the promigratory tyrosine kinase receptor Her2/Neu) were analyzed within a bimodal framework that is a generalization of the run-and-tumble description applicable to bacterial migration. The mammalian cell trajectories were segregated into two types of alternating modes, namely, the "directional mode" (mode I, the more persistent mode, analogous to the bacterial run phase) and the "re-orientation mode" (mode II, the less persistent mode, analogous to the bacterial tumble phase). Higher resolution (more pixel information, relative to cell size) and smaller sampling intervals (time between images) were found to give a better estimate of the deduced single cell dynamics (such as directional-mode time and turn angle distribution) of the various cell types from the bimodal analysis. The bimodal analysis tool permits the deduction of short-time dynamics of cell motion such as the turn angle distributions and turn frequencies during the course of cell migration compared to standard methods of cell migration analysis. We find that the 2-h mammalian cell tracking data do not fall into the diffusive regime implying that the often-used random motility expressions for mammalian cell motion (based on assuming diffusive motion) are invalid over the time steps (fraction of minute) typically used in modeling mammalian cell migration.
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