ReviewEuropean journal of nuclear medicine and molecular imaging2009
Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries.
Review in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
- A Randomized Placebo-Controlled Trial of Secukinumab on Aortic Vascular Inflammation in Moderate-to-Severe Plaque Psoriasis (VIP-S).The Journal of investigative dermatology · 2020Trial
- A Phase IV, Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effects of Ustekinumab on Vascular Inflammation in Psoriasis (the VIP-U Trial).The Journal of investigative dermatology · 2020Trial
- Effect of 2 Psoriasis Treatments on Vascular Inflammation and Novel Inflammatory Cardiovascular Biomarkers: A Randomized Placebo-Controlled Trial.Circulation. Cardiovascular imaging · 2018Trial
- The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers.European journal of nuclear medicine and molecular imaging · 2012Trial
- Associations of subclinical microcalcification and inflammation with carotid atheroma development: a dual-tracer PET/CT study.European journal of nuclear medicine and molecular imaging · 2025Observational
- Advanced molecular imaging in large-vessel vasculitis: Adopting FDG-PET into a clinical workflow.Best practice & research. Clinical rheumatology · 2023Review
- Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall.Clinical science (London, England : 1979) · 2022Review
- Article
- Diagnostic Role and Feasibility ofAnnals of nuclear cardiology · 2020Review
- Detection of pulmonary artery atherosclerosis by FDG-PET/CT: a new observation.American journal of nuclear medicine and molecular imaging · 2020Article
- Psoas muscle fluorine-18-labelled fluoro-2-deoxy-d-glucose uptake associated with the incidence of existing and incipient metabolic derangement.Journal of cachexia, sarcopenia and muscle · 2019Article
- Metabolic influence on macrophage polarization and pathogenesis.BMB reports · 2019Review
- Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018 · on this mapArticle
- Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Assessment of atherosclerosis in large vessel walls: A comprehensive review of FDG-PET/CT image acquisition protocols and methods for uptake quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Growing applications of FDG PET-CT imaging in non-oncologic conditions.Journal of biomedical research · 2015Article
- Implications of Pericardial, Visceral and Subcutaneous Adipose Tissue on Vascular Inflammation Measured Using 18FDG-PET/CT.PloS one · 2015Article
- Identification of inflamed atherosclerotic lesions in vivo using PET-CT.Inflammation · 2014Article
- PET/MRI: current state of the art and future potential for cardiovascular applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Radiotracer imaging of peripheral vascular disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Atherosclerosis is a dynamic inflammatory disorder. The biological composition and inflammatory state of an atherosclerotic plaque, rather than the degree of stenosis or its size are the major determinants of acute clinical events. A noninvasive technique to detect vulnerable atherosclerotic plaque is critically needed. FDG-PET/CT, a combined functional and structural whole-body imaging modality, holds great potential for this purpose. FDG uptake in large arteries has been frequently observed and is associated with cardiovascular risk factors. FDG accumulates in plaque macrophages and uptake is correlated with macrophage density. It is known that vascular FDG uptake and calcification do not overlap significantly and changes of FDG uptake are common, suggesting that FDG uptake may represent a dynamic inflammatory process. It has been reported that vascular FDG uptake can be attenuated by simvastatin in patients, and by the antiinflammatory drug probucol in rabbits. Vascular FDG uptake has been linked to cardiovascular events in some preliminary studies. Data from basic sciences, and animal and clinical studies support the emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.