ArticleFrontiers in neuroscience2008
Layer, column and cell-type specific genetic manipulation in mouse barrel cortex.
Article in Frontiers in neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
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- Independent representations of self-motion and object location in barrel cortex output.PLoS biology · 2020Article
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- Dual-Channel Photostimulation for Independent Excitation of Two Populations.Current protocols in neuroscience · 2018Article
- Circuit-specific and neuronal subcellular-wide E-I balance in cortical pyramidal cells.Scientific reports · 2018Article
- Intracellular CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Immunoreactivities of calbindin‑D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging.Molecular medicine reports · 2017Article
- Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation.Scientific reports · 2013Article
- Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Genomewide analysis of rat barrel cortex reveals time- and layer-specific mRNA expression changes related to experience-dependent plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Single axon branching analysis in rat thalamocortical projection from the anteroventral thalamus to the granular retrosplenial cortex.Frontiers in neuroanatomy · 2011Article
- Targeted single-cell electroporation of mammalian neurons in vivo.Nature protocols · 2009Article
- Feature selectivity of the gamma-band of the local field potential in primate primary visual cortex.Frontiers in neuroscience · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory information is processed in distributed neuronal networks connected by intricate synaptic circuits. Studies of the rodent brain can provide insight into synaptic mechanisms of sensory perception and associative learning. In particular, the mouse whisker sensorimotor system has recently begun to be investigated through combinations of imaging and electrophysiology, providing data correlating neural activity with behaviour. In order to go beyond such correlative studies and to pinpoint the contributions of individual genes to brain function, it is critical to make highly controlled and specific manipulations. Here, we review recent progress towards genetic manipulation of targeted genes in specific neuronal cell types located in a selected cortical layer of a well-defined cortical column of mouse barrel cortex. The unprecedented precision of such genetic manipulation within highly specific neural circuits may contribute significantly to progress in understanding the molecular and synaptic determinants of simple forms of sensory perception and associative learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.