ArticlePloS one2008
Functional diffusion tensor imaging: measuring task-related fractional anisotropy changes in the human brain along white matter tracts.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Trial
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Volume of the hypothalamus and its subunits in patients with episodic migraine without aura during interictal periods.The journal of headache and pain · 2025Article
- Multiple Classification of Brain MRI Autism Spectrum Disorder by Age and Gender Using Deep Learning.Journal of medical systems · 2024Article
- Diffusion tensor imaging study of the microstructural changes in the white matter of patients with herpes zoster and postherpetic neuralgia.American journal of translational research · 2022Article
- Thalamo-cortical networks in subtypes of migraine with aura patients.The journal of headache and pain · 2021Article
- Covariation Between Brain Function (MEG) and Structure (DTI) Differentiates Adolescents with Fetal Alcohol Spectrum Disorder from Typically Developing Controls.Neuroscience · 2020Article
- Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile.The journal of headache and pain · 2020Article
- No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial.Frontiers in psychiatry · 2020Article
- MRI-based assessment of function and dysfunction in myelinated axons.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Structural neuroimaging as clinical predictor: A review of machine learning applications.NeuroImage. Clinical · 2018Review
- Right Forceps Minor and Anterior Thalamic Radiation Predict Executive Function Skills in Young Bilingual Adults.Frontiers in psychology · 2018Article
- Mapping white-matter functional organization at rest and during naturalistic visual perception.NeuroImage · 2017Article
- Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis.The journal of headache and pain · 2016Article
- Longitudinal changes in free-water within the substantia nigra of Parkinson's disease.Brain : a journal of neurology · 2015Article
- Coupled changes in brain white matter microstructure and fluid intelligence in later life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy.Human brain mapping · 2015Article
- White matter development in the early stages of psychosis.Schizophrenia research · 2015Review
- Structural brain network imaging shows expanding disconnection of the motor system in amyotrophic lateral sclerosis.Human brain mapping · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional neural networks in the human brain can be studied from correlations between activated gray matter regions measured with fMRI. However, while providing important information on gray matter activation, no information is gathered on the co-activity along white matter tracts in neural networks. METHODOLOGY/PRINCIPAL
findingsWe report on a functional diffusion tensor imaging (fDTI) method that measures task-related changes in fractional anisotropy (FA) along white matter tracts. We hypothesize that these fractional anisotropy changes relate to morphological changes of glial cells induced by axonal activity although the exact physiological underpinnings of the measured FA changes remain to be elucidated. As expected, these changes are very small as compared to the physiological noise and a reliable detection of the signal change would require a large number of measurements. However, a substantial increase in signal-to-noise ratio was achieved by pooling the signal over the complete fiber tract. Adopting such a tract-based statistics enabled us to measure the signal within a practically feasible time period. Activation in the sensory thalamocortical tract and optic radiation in eight healthy human subjects was found during tactile and visual stimulation, respectively. CONCLUSIONS/SIGNIFICANCE: The results of our experiments indicate that these FA changes may serve as a functional contrast mechanism for white matter. This noninvasive fDTI method may provide a new approach to study functional neural networks in the human brain.
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