ArticleGenes & development2008
Intraspecific evolution of the intercellular signaling network underlying a robust developmental system.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 93 citations in OpenAlex.
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- Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- Quantifying cell transitions in C. elegans with data-fitted landscape models.PLoS computational biology · 2021Article
- A Cell Fate Switch in theGenetics · 2020Article
- Evolution and Developmental System Drift in the Endoderm Gene Regulatory Network ofFrontiers in cell and developmental biology · 2020Review
- Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits.G3 (Bethesda, Md.) · 2019Article
- Developmental Plasticity and Cellular Reprogramming inGenetics · 2019Review
- Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network.eLife · 2019Article
- The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions inLife science alliance · 2019Article
- Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt, and Semaphorin Pathways in Vulval Induction of the NematodeGenetics · 2019Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- Chaperones, Canalization, and Evolution of Animal Forms.International journal of molecular sciences · 2018Review
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Physiological Starvation PromotesG3 (Bethesda, Md.) · 2018Article
- Article
- How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects.PLoS genetics · 2017Article
- Article
- The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape.G3 (Bethesda, Md.) · 2017Article
- Heterotaxy in Caenorhabditis: widespread natural variation in left-right arrangement of the major organs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many biological systems produce an invariant output when faced with stochastic or environmental variation. This robustness of system output to variation affecting the underlying process may allow for "cryptic" genetic evolution within the system without change in output. We studied variation of cell fate patterning of Caenorhabditis elegans vulva precursors, a developmental system that relies on a simple intercellular signaling network and yields an invariant output of cell fates and lineages among C. elegans wild isolates. We first investigated the system's genetic variation in C. elegans by means of genetic tools and cell ablation to break down its buffering mechanisms. We uncovered distinct architectures of quantitative variation along the Ras signaling cascade, including compensatory variation, and differences in cell sensitivity to induction along the anteroposterior axis. In the unperturbed system, we further found variation between isolates in spatio-temporal dynamics of Ras pathway activity, which can explain the phenotypic differences revealed upon perturbation. Finally, the variation mostly affects the signaling pathways in a tissue-specific manner. We thus demonstrate and characterize microevolution of a developmental signaling network. In addition, our results suggest that the vulva genetic screens would have yielded a different mutation spectrum, especially for Wnt pathway mutations, had they been performed in another C. elegans genetic background.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.