ArticleArchives of general psychiatry2008
Aberrant brain activation during gaze processing in boys with fragile X syndrome.
Article in Archives of general psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome.PloS one · 2019Trial
- Emotion potentiated startle in fragile X syndrome.Journal of autism and developmental disorders · 2014Trial
- STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study.Journal of autism and developmental disorders · 2014Trial
- Longitudinal Changes in Functional Neural Activation and Sensitization During Face Processing in Fragile X Syndrome.Biological psychiatry · 2025Article
- Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.Journal of autism and developmental disorders · 2024Article
- Observable Symptoms of Anxiety in Individuals with Fragile X Syndrome: Parent and Caregiver Perspectives.Genes · 2022Article
- Aberrant brain network and eye gaze patterns during natural social interaction predict multi-domain social-cognitive behaviors in girls with fragile X syndrome.Molecular psychiatry · 2022Article
- Is there collaboration specific neurophysiological activation during collaborative task activity? An analysis of brain responses using electroencephalography and hyperscanning.Brain and behavior · 2021Article
- Developmental studies in fragile X syndrome.Journal of neurodevelopmental disorders · 2020Review
- Language Performance in Preschool-Aged Boys with Nonsyndromic Autism Spectrum Disorder or Fragile X Syndrome.Journal of autism and developmental disorders · 2020Article
- A novel eye-tracking paradigm for indexing social avoidance-related behavior in fragile X syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Article
- [Hidden Markov models for human interactive behavior].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study.Journal of neurodevelopmental disorders · 2019Article
- Overview of Social Cognitive Dysfunctions in Rare Developmental Syndromes With Psychiatric Phenotype.Frontiers in pediatrics · 2018Review
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome.Molecular autism · 2017Article
- Moving Toward Integrative, Multidimensional Research in Modern Psychiatry: Lessons Learned From Fragile X Syndrome.Biological psychiatry · 2016Review
- The basolateral amygdala γ-aminobutyric acidergic system in health and disease.Journal of neuroscience research · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
contextEye contact is a fundamental component of human social behavior. Individuals with fragile X syndrome (fraX), particularly male subjects, avoid eye contact and display other social deficits. To date (to our knowledge), this behavior in fraX has been studied only in female subjects, who show lesser degrees of gaze aversion.
objectiveTo determine the neural correlates of the perception of direct eye gaze in adolescent boys with fraX using functional magnetic resonance imaging.
designCross-sectional study.
settingAcademic medical center.
participantsThirteen adolescent boys with fraX, 10 boys with developmental delay, and 13 typically developing control subjects.
main outcome measuresBehavioral performance and brain activation during functional magnetic resonance imaging were evaluated during the presentation of faces with eye gaze directed to or averted away from subjects and during successive presentations of stimuli with eye gaze directed toward the subject. Whole-brain and region of interest analyses and regression analyses with task performance were performed.
resultsSignificantly greater activation was observed in prefrontal cortices in controls compared with boys having fraX, who (in contrast) demonstrated elevated left insula activation to direct eye gaze stimuli. Furthermore, compared with controls, boys with fraX showed greater sensitization in the left amygdala with successive exposure to direct gaze.
conclusionsCompared with controls, boys with fraX display distinct patterns of brain activation in response to direct eye gaze. These results suggest that aberrant neural processing of direct eye gaze in subjects with fraX may be related to the associated avoidant response.
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