ArticleHypertension (Dallas, Tex. : 1979)2008
Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/phosphatidylinositol 3-kinase complex to promote endothelial nitric oxide synthase phosphorylation.
Article in Hypertension (Dallas, Tex. : 1979), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the No-Touch Technique.Journal of the American Heart Association · 2022Article
- Novel Paradigms of Salt and Hypertension.Journal of the American Society of Nephrology : JASN · 2017Review
- Transforming growth factor-β mediates endothelial dysfunction in rats during high salt intake.American journal of physiology. Renal physiology · 2015Article
- Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.American journal of physiology. Renal physiology · 2014Article
- Transforming growth factor-β regulates endothelial function during high salt intake in rats.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Effect of dietary salt on regulation of TGF-β in the kidney.Seminars in nephrology · 2012Article
- Effect of aging and dietary salt and potassium intake on endothelial PTEN (Phosphatase and tensin homolog on chromosome 10) function.PloS one · 2012Article
- Pivotal role of apoptosis signal-regulating kinase 1 in monoclonal free light chain-mediated apoptosis.The American journal of pathology · 2012Article
- Mechanisms and consequences of salt sensitivity and dietary salt intake.Current opinion in nephrology and hypertension · 2011Review
- Vascular consequences of dietary salt intake.American journal of physiology. Renal physiology · 2009Review
- Dietary salt intake, salt sensitivity, and cardiovascular health.Hypertension (Dallas, Tex. : 1979) · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although many laboratories have shown that dietary NaCl (salt) intake increases NO production in rodents and humans, the mechanism has not been uncovered. In the present study, pharmacological and dominant-negative strategies were used to show that feeding a formulated diet containing increased amounts of salt to young male Sprague-Dawley rats induced the formation of an endothelial cell-signaling complex that contained proline-rich tyrosine kinase 2, c-Src (also known as pp60(c-src)), and phosphatidylinositol 3-kinase. In the setting of a high-salt diet, proline-rich tyrosine kinase 2 served as the scaffold for c-Src-mediated phosphatidylinositol 3-kinase activation. Phosphatidylinositol 3-kinase was the upstream activator of protein kinase B (Akt), which was responsible for phosphorylation of the rat endothelial isoform of NO synthase at S1176 and thereby promoted the increase in NO production. The combined findings illustrated the crucial role for a proline-rich tyrosine kinase 2-signaling complex in the endothelial response to salt intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.