ArticleInfection and immunity2009
A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Response of the Biocontrol Agent Pseudomonas pseudoalcaligenes AVO110 to Rosellinia necatrix Exudate.Applied and environmental microbiology · 2019Article
- An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.BMC microbiology · 2017Article
- Screening of genes involved in interactions with intestinal epithelial cells in Cronobacter sakazakii.AMB Express · 2016Article
- Article
- A novel DNA-binding protein plays an important role in Helicobacter pylori stress tolerance and survival in the host.Journal of bacteriology · 2015Article
- High correlation of babA 2-positive strains of Helicobacter pylori with the presence of gastric cancer.Internal and emergency medicine · 2013Article
- Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes.PloS one · 2013Article
- Article
- A histone-like protein of Helicobacter pylori protects DNA from stress damage and aids host colonization.DNA repair · 2012Article
- DprB facilitates inter- and intragenomic recombination in Helicobacter pylori.Journal of bacteriology · 2012Article
- Biochemical and cellular characterization of Helicobacter pylori RecA, a protein with high-level constitutive expression.Journal of bacteriology · 2011Article
- The RecRO pathway of DNA recombinational repair in Helicobacter pylori and its role in bacterial survival in the host.DNA repair · 2011Article
- Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination.Molecular microbiology · 2011Article
- Recombination and DNA repair in Helicobacter pylori.Annual review of microbiology · 2011Review
- Peptidoglycan deacetylation in Helicobacter pylori contributes to bacterial survival by mitigating host immune responses.Infection and immunity · 2010Article
- Phylogenetic ubiquity and shuffling of the bacterial RecBCD and AddAB recombination complexes.Journal of bacteriology · 2009Article
- Detection and Genotyping ofPakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The human gastric pathogen Helicobacter pylori encounters frequent oxidative and acid stress in its specific niche, and this causes bacterial DNA damage. H. pylori exhibits a very high degree of DNA recombination, which is required for repairing both DNA double-stranded (ds) breaks and blocked replication forks. Nevertheless, few genes encoding components of DNA recombinational repair processes have been identified in H. pylori. An H. pylori mutant defective in a putative helicase gene (HP1553) was constructed and characterized herein. The HP1553 mutant strain was much more sensitive to mitomycin C than the WT strain, indicating that HP1553 is required for repair of DNA ds breaks. Disruption of HP1553 resulted in a significant decrease in the DNA recombination frequency, suggesting that HP1553 is involved in DNA recombination processes, probably functioning as a RecB-like helicase. HP1553 was shown to be important for H. pylori protection against oxidative stress-induced DNA damage, as the exposure of the HP1553 mutant cells to air for 6 h caused significant fragmentation of genomic DNA and led to cell death. In a mouse infection model, the HP1553 mutant strain displayed a greatly reduced ability to colonize the host stomachs, indicating that HP1553 plays a significant role in H. pylori survival/colonization in the host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.