ArticleMolecular and cellular biology2009
Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Mechanisms of Feedback Regulation of Vitamin A Metabolism.Nutrients · 2022Review
- Aldehyde Oxidase Contributes to All-Drug metabolism and disposition: the biological fate of chemicals · 2021Article
- Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae).Journal of insect science (Online) · 2020Article
- Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes.The Journal of biological chemistry · 2020Review
- Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.Pharmacology & therapeutics · 2019Review
- Outer Membrane Protein of Gut Commensal Microorganism Induces Autoantibody Production and Extra-Intestinal Gland Inflammation in Mice.International journal of molecular sciences · 2018Article
- Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities.PloS one · 2018Article
- Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.Scientific reports · 2016Article
- Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.Immunity · 2015Article
- Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner.Biochemical pharmacology · 2015Article
- Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer.Advances in pharmacology (San Diego, Calif.) · 2015Review
- The mononuclear molybdenum enzymes.Chemical reviews · 2014Review
- Inhibition of xanthine oxidase by the aldehyde oxidase inhibitor raloxifene: implications for identifying molybdopterin nitrite reductases.Nitric oxide : biology and chemistry · 2014Article
- Identification and characterization of sebaceous gland atrophy-sparing DGAT1 inhibitors.PloS one · 2014Article
- Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression.Cellular and molecular life sciences : CMLS · 2013Article
- Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity.PloS one · 2013Article
- The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.The Journal of biological chemistry · 2012Article
- The impact of single nucleotide polymorphisms on human aldehyde oxidase.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- Molybdenum enzymes in higher organisms.Coordination chemistry reviews · 2011Article
- Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets.The Journal of biological chemistry · 2011Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
The mouse aldehyde oxidase AOH2 (aldehyde oxidase homolog 2) is a molybdoflavoenzyme. Harderian glands are the richest source of AOH2, although the protein is detectable also in sebaceous glands, epidermis, and other keratinized epithelia. The levels of AOH2 in the Harderian gland and skin are controlled by genetic background, being maximal in CD1 and C57BL/6 and minimal in DBA/2, CBA, and 129/Sv strains. Testosterone is a negative regulator of AOH2 in Harderian glands. Purified AOH2 oxidizes retinaldehyde into retinoic acid, while it is devoid of pyridoxal-oxidizing activity. Aoh2(-/-) mice, the first aldehyde oxidase knockout animals ever generated, are viable and fertile. The data obtained for this knockout model indicate a significant role of AOH2 in the local synthesis and biodisposition of endogenous retinoids in the Harderian gland and skin. The Harderian gland's transcriptome of knockout mice demonstrates overall downregulation of direct retinoid-dependent genes as well as perturbations in pathways controlling lipid homeostasis and cellular secretion, particularly in sexually immature animals. The skin of knockout mice is characterized by thickening of the epidermis in basal conditions and after UV light exposure. This has correlates in the corresponding transcriptome, which shows enrichment and overall upregulation of genes involved in hypertrophic responses.
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