ArticleJournal of immunology (Baltimore, Md. : 1950)2008
A new mechanism for inhalational priming: IL-4 bypasses innate immune signals.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Birch Pollen Induces Toll-Like Receptor 4-Dependent Dendritic Cell Activation Favoring T Cell Responses.Frontiers in allergy · 2021Article
- Initiating pollen sensitization - complex source, complex mechanisms.Clinical and translational allergy · 2020Review
- Cellular and Molecular Events in the Airway Epithelium Defining the Interaction Between House Dust Mite Group 1 Allergens and Innate Defences.International journal of molecular sciences · 2018Review
- Context matters: TThe Journal of allergy and clinical immunology · 2018Article
- Cytokines in sensitization to aeroallergens.Allergologie select · 2018Review
- Suppression of Th17-polarized airway inflammation by rapamycin.Scientific reports · 2017Article
- B Cell-ExtrinsicJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming.The Journal of investigative dermatology · 2015Article
- CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.Nature immunology · 2014Article
- Recombinant house dust mite allergens.Methods (San Diego, Calif.) · 2014Article
- Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- T(H)17 cells mediate pulmonary collateral priming.The Journal of allergy and clinical immunology · 2011Article
- Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens.Infection and immunity · 2011Article
- Importance of cytokines in murine allergic airway disease and human asthma.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Signaling via innate immune mechanisms is considered pivotal for T cell-mediated responses to inhaled Ags. Furthermore, Th2 cells specific for one inhaled Ag can facilitate priming of naive T cells to unrelated new inhaled Ags, a process we call "Th2 collateral priming". Interestingly, our previous studies showed that collateral priming is independent of signals via the innate immune system but depends on IL-4 secretion by CD4(+) T cells. We thus hypothesized that IL-4 can bypass the need for signals via the innate immune system, considered essential for pulmonary priming. Indeed, we were able to show that IL-4 bypasses the requirement for TLR4- and MyD88-mediated signaling for responses to new allergens. Furthermore, we characterized the mechanisms by which IL-4 primes for new inhaled allergens: "IL-4-dependent pulmonary priming" relies on IL-4 receptor expression on hematopoietic cells and structural cells. Transfer experiments indicate that within the hematopoietic compartment both T cells and dendritic cells need to express the IL-4 receptor. Finally, we were able to show that IL-4 induces recruitment and maturation of myeloid dendritic cells in vivo and increases T cell recruitment to the draining lymph nodes. Our findings bring new mechanistic knowledge to the phenomenon of polysensitization and primary sensitization in asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.