ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Antiviral-activated dendritic cells: a paracrine-induced response state.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
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- Small-molecule TIP60 inhibitors enhance regulatory T cell induction through TIP60-P300 acetylation crosstalk.iScience · 2023Article
- Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity.Immunity · 2023Article
- Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.Immunity · 2022Article
- Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use.Frontiers in cellular and infection microbiology · 2022Review
- Interpretation of an individual functional genomics experiment guided by massive public data.Nature methods · 2018Article
- Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.Nature communications · 2017Article
- Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells.Pflugers Archiv : European journal of physiology · 2016Article
- Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism.BMC immunology · 2015Article
- Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.Journal of theoretical biology · 2014Article
- Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells.PloS one · 2014Article
- Combinatorial cytokine code generates anti-viral state in dendritic cells.Frontiers in immunology · 2014Article
- Preservation of dendritic cell function during vesicular stomatitis virus infection reflects both intrinsic and acquired mechanisms of resistance to suppression of host gene expression by viral M protein.Journal of virology · 2013Article
- A quantitative infection assay for human type I, II, and III interferon antiviral activities.Virology journal · 2013Article
- Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.The Journal of biological chemistry · 2013Article
- Germinal center texture entropy as possible indicator of humoral immune response: immunophysiology viewpoint.Molecular imaging and biology · 2012Article
- Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.PloS one · 2012Article
- Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells.Immunology and cell biology · 2011Article
- Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus.The Journal of infectious diseases · 2011Article
- Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Infection of immature dendritic cells (DCs) by virus stimulates their maturation into APC. Infected DCs can also expose uninfected DCs to a panoply of cytokines/chemokines via paracrine signaling. Mathematical modeling suggests that a high rate of paracrine signaling is likely to occur among DCs located in three-dimensional space. Relatively little is known about how secreted factors modify the early response to virus infection. We used a transwell experimental system that allows passage of secreted factors, but not direct contact, between virus-infected DCs and uninfected DCs to investigate paracrine signaling responses. Paracrine signaling from infected DCs induced an antiviral-primed DC state distinct from that of mature virus-infected DCs that we refer to as antiviral-activated DCs (AVDCs). AVDCs had increased surface MHC class II and CD86 levels, but in contrast to virus-infected DCs, their MHC class I levels were unchanged. Imaging flow cytometry showed that AVDCs had an increased rate of phagocytosis compared with naive DCs. Experiments with IFN-beta cytokine indicated that it may be responsible for CD86, but not MHC class II regulation in AVDCs. Both IFN-inducible and IFN-independent genes are up-regulated in AVDCs. Notably, AVDCs are relatively resistant to virus infection in comparison to naive DCs and achieve accelerated and augmented levels of costimulatory molecule expression with virus infection. AVDCs show a distinct antiviral-primed state of DC maturation mediated by DC paracrine signaling. Although further in vivo study is needed, the characteristics of the AVDC suggest that it is well suited to play a role in the early innate-adaptive transition of the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.