ArticleClinical cancer research : an official journal of the American Association for Cancer Research2008
Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 156 citations in OpenAlex.
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- Exploring the links among inflammation and gut microbiome with psychoneurological symptoms and gastrointestinal toxicities in gynecologic cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates.BMJ open · 2015Pooled it
- Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.Psychoneuroendocrinology · 2016Trial
- Randomized controlled trial of expressive writing for patients with renal cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Trial
- Cancer-related intrusive thoughts predict behavioral symptoms following breast cancer treatment.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014Trial
- Depressive symptoms and cortisol rhythmicity predict survival in patients with renal cell carcinoma: role of inflammatory signaling.PloS one · 2012Trial
- Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.Brain, behavior, & immunity - health · 2026Review
- Stress Biology in Cancer: Neuroendocrine-Immune Mechanisms Linking Tumor Progression to Translational Interventions.Cancer communications (London, England) · 2026Review
- Chronic stress-related neuroendocrine mediators and ovarian cancer.Discover oncology · 2025Review
- Morpho-Functional and Biochemical Characterization of Adrenal Masses in a Heterogeneous Cancer Population.Cancers · 2025Article
- Coping Styles and Defense Mechanisms in Healthy Young Adults-Correlations with tPA-BDNF Pathway.Brain sciences · 2025Article
- The genetic association between major depressive disorder and coronary heart disease.Acta neuropsychiatrica · 2025Article
- Caregiver burden and risk of epithelial ovarian cancer in the Nurses' Health Studies.American journal of epidemiology · 2025Article
- Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024.Discover oncology · 2025Article
- Living Well: Protocol for a web-based program to improve quality of life in rural and urban ovarian cancer survivors.Contemporary clinical trials · 2024Article
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- Impact of implant surface type on breast cancer relapse after breast reconstruction: propensity score-matched study.The British journal of surgery · 2023Article
- Wip1 contributes to the adaptation of HepG2 human liver cancer cells to stress hormone-induced DNA damage.Oncology letters · 2023Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeStromal cells in the tumor microenvironment, such as macrophages, play an active role in tumor growth and angiogenesis. However, little is known about relationships of biobehavioral factors with angiogenic cytokines and matrix metalloproteinases (MMP) produced by stromal cells. This study examined distress, MMPs, and angiogenic cytokines in ovarian cancer patients and in vitro. EXPERIMENTAL
designPatients suspected of ovarian cancer completed preoperative questionnaires. At surgery, 56 were confirmed to have epithelial ovarian cancer. Tumor samples were analyzed for macrophage (CD68(+)) and tumor cell levels of MMP-2, MMP-9, and vascular endothelial growth factor. In vitro stimulation of isolated macrophage cells by the stress hormones norepinephrine and cortisol was done to assess effects on MMP-9.
resultsDepressed patients showed significant elevations of MMP-9 in CD68(+) cells, adjusting for stage (P<0.0001). Patients with higher levels of current stress (P=0.01), life stress over the last 6 months (P=0.004), and general negative affect (P=0.007) also showed significantly greater MMP-9 in CD68(+) cells. In contrast, higher social support was associated with lower levels of MMP-9 (P=0.023) and vascular endothelial growth factor (P=0.036) in tumor cells. In vitro analyses showed that macrophage MMP-9 production could be directly enhanced (up to a 2-fold increase) by the stress hormones norepinephrine and cortisol.
conclusionsOvarian cancer patients with elevated depressive symptoms, chronic stress, and low social support showed elevations in MMP-9 in tumor-associated macrophages. Direct in vitro enhancement of stromal MMP-9 production by stress hormones was also shown. These findings may have implications for patient outcomes in ovarian cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.