ReviewCurrent psychiatry reports2008
A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder.
Review in Current psychiatry reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Adenosine AMolecular neurobiology · 2022Article
- The Role of PKC and HIF-1 and the Effect of Traditional Chinese Medicinal Compounds on Cerebral Ischemia-Reperfusion Injury.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine.Molecular neurobiology · 2018Article
- Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain.The international journal of neuropsychopharmacology · 2017Article
- Polyphenol compounds and PKC signaling.Biochimica et biophysica acta · 2016Review
- Inositol depletion, GSK3 inhibition and bipolar disorder.Future neurology · 2016Review
- Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania.Molecular neurobiology · 2015Article
- Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2014Review
- Tamoxifen use for the management of mania: a review of current preclinical evidence.Psychopharmacology · 2014Review
- Protein kinase C, an elusive therapeutic target?Nature reviews. Drug discovery · 2012Review
- Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.Psychiatry research · 2012Article
- Requirement of phospholipase C and protein kinase C in cholecystokinin-mediated facilitation of NMDA channel function and anxiety-like behavior.Hippocampus · 2012Article
- Review of pharmacological treatment in mood disorders and future directions for drug development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
- New drugs for bipolar disorder.Current psychiatry reports · 2011Review
- Predictive animal models of mania: hits, misses and future directions.British journal of pharmacology · 2011Review
- Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.Molecular psychiatry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this article, we review preclinical studies investigating the role of protein kinase C (PKC) as it pertains to mania and effective antimanic agents. We then discuss clinical studies conducted with tamoxifen, a relatively selective PKC inhibitor, in acute bipolar mania. We conclude that PKC is an important target-arguably the first mechanistically distinct drug target for bipolar disorder. PKC holds considerable promise as a novel target for developing a new line of treatments for bipolar disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.