ArticleBMC evolutionary biology2008
Evolutionary history of the UCP gene family: gene duplication and selection.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Evolution ofInternational journal of molecular sciences · 2025Article
- The evolution of bitter taste receptor gene in primates: Gene duplication and selection.Ecology and evolution · 2023Article
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- Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases.International journal of molecular sciences · 2022Review
- Uncoupling proteins in the mitochondrial defense against oxidative stress.Progress in retinal and eye research · 2021Review
- Dynamics of transcriptome changes during subcutaneous preadipocyte differentiation in ducks.BMC genomics · 2019Article
- Being right on Q: shaping eukaryotic evolution.The Biochemical journal · 2016Review
- Functional and Activity Analysis of Cattle UCP3 Promoter with MRFs-Related Factors.International journal of molecular sciences · 2016Article
- Mitochondrial uncoupling protein 2 and pancreatic cancer: a new potential target therapy.World journal of gastroenterology · 2015Review
- Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.Heart failure reviews · 2015Review
- How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Tissue-specific gene expression and functional regulation of uncoupling protein 2 (UCP2) by hypoxia and nutrient availability in gilthead sea bream (Sparus aurata): implications on the physiological significance of UCP1-3 variants.Fish physiology and biochemistry · 2014Article
- Life-history Constraints on the Mechanisms that Control the Rate of ROS Production.Current genomics · 2014Article
- The nocturnal bottleneck and the evolution of activity patterns in mammals.Proceedings. Biological sciences · 2013Review
- Genomic characterization of the European sea bass Dicentrarchus labrax reveals the presence of a novel uncoupling protein (UCP) gene family member in the teleost fish lineage.BMC evolutionary biology · 2012Article
- Article
- Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution.BMC evolutionary biology · 2011Article
- In vivo analysis of white adipose tissue in zebrafish.Methods in cell biology · 2011Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe uncoupling protein (UCP) genes belong to the superfamily of electron transport carriers of the mitochondrial inner membrane. Members of the uncoupling protein family are involved in thermogenesis and determining the functional evolution of UCP genes is important to understand the evolution of thermo-regulation in vertebrates.
resultsSequence similarity searches of genome and scaffold data identified homologues of UCP in eutherians, teleosts and the first squamates uncoupling proteins. Phylogenetic analysis was used to characterize the family evolutionary history by identifying two duplications early in vertebrate evolution and two losses in the avian lineage (excluding duplications within a species, excluding the losses due to incompletely sequenced taxa and excluding the losses and duplications inferred through mismatch of species and gene trees). Estimates of synonymous and nonsynonymous substitution rates (dN/dS) and more complex branch and site models suggest that the duplication events were not associated with positive Darwinian selection and that the UCP is constrained by strong purifying selection except for a single site which has undergone positive Darwinian selection, demonstrating that the UCP gene family must be highly conserved.
conclusionWe present a phylogeny describing the evolutionary history of the UCP gene family and show that the genes have evolved through duplications followed by purifying selection except for a single site in the mitochondrial matrix between the 5th and 6th alpha-helices which has undergone positive selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.