ReviewExpert review of vaccines2008
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Review in Expert review of vaccines, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Viral Respiratory Pathogens and Lung Injury.Clinical microbiology reviews · 2021Review
- Article
- Cytokine production in whole-blood cultures following immunization with an influenza vaccine.Human vaccines & immunotherapeutics · 2018Article
- An innate antiviral pathway acting before interferons at epithelial surfaces.Nature immunology · 2016Article
- Intranasal Immunization of Mice to Avoid Interference of Maternal Antibody against H5N1 Infection.PloS one · 2016Article
- Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Production of inflammatory cytokines in response to diphtheria-pertussis-tetanus (DPT), haemophilus influenzae type b (Hib), and 7-valent pneumococcal (PCV7) vaccines.Human vaccines & immunotherapeutics · 2014Article
- Inflammasomes in antiviral immunity: clues for influenza vaccine development.Clinical and experimental vaccine research · 2014Review
- Mucosal immunization with recombinant adenovirus encoding soluble globular head of hemagglutinin protects mice against lethal influenza virus infection.Immune network · 2013Article
- Construction of the influenza A virus infection-induced cell-specific inflammatory regulatory network based on mutual information and optimization.BMC systems biology · 2013Article
- FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Principles underlying rational design of live attenuated influenza vaccines.Clinical and experimental vaccine research · 2012Article
- Cold-adapted pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against seasonal and H5 influenza A viruses.Journal of virology · 2012Article
- Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.PLoS pathogens · 2012Article
- Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.PLoS pathogens · 2012Article
- Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice.PloS one · 2011Article
- Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development.Virology journal · 2010Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mucosal immunity acquired by natural infection with influenza viruses at the respiratory tract is more effective and cross-protective against subsequent variant virus infection than systemic immunity induced by parenteral immunization with inactivated vaccines. To develop an effective influenza vaccine, it is beneficial to mimic the process of natural infection that bridges innate and adaptive immune systems. The innate immune system that recognizes influenza virus infection consists of several classes of pattern-recognition receptors, including the Toll-like receptors, the retinoic acid-inducible gene-I-like receptors and the NOD-like receptors. Here, we review our current understanding of the mechanism of innate recognition of influenza and how the signals emanating from the innate sensors control adaptive immunity. Further, we discuss the potential roles of these receptors in developing intranasal influenza vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.