ArticlePloS one2008
Comprehensive characterization of molecular interactions based on nanomechanics.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- A suspended graphene-based optical interferometric surface stress sensor for selective biomolecular detection.Nanoscale advances · 2020Article
- Optical-Interferometry-Based CMOS-MEMS Sensor Transduced by Stress-Induced Nanomechanical Deflection.Sensors (Basel, Switzerland) · 2018Article
- Accurate characterization of benign and cancerous breast tissues: aspecific patient studies using piezoresistive microcantilevers.Biosensors & bioelectronics · 2015Article
- Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer.Lab on a chip · 2015Article
- Mechanical phenotyping of breast cancer using MEMS: a method to demarcate benign and cancerous breast tissues.Lab on a chip · 2014Article
- Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum.Nature nanotechnology · 2014Article
- Two dimensional array of piezoresistive nanomechanical Membrane-type Surface Stress Sensor (MSS) with improved sensitivity.Sensors (Basel, Switzerland) · 2012Article
- Approaches to increasing surface stress for improving signal-to-noise ratio of microcantilever sensors.Analytical chemistry · 2010Review
- Experimental and computational characterization of biological liquid crystals: a review of single-molecule bioassays.International journal of molecular sciences · 2009Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular interaction is a key concept in our understanding of the biological mechanisms of life. Two physical properties change when one molecular partner binds to another. Firstly, the masses combine and secondly, the structure of at least one binding partner is altered, mechanically transducing the binding into subsequent biological reactions. Here we present a nanomechanical micro-array technique for bio-medical research, which not only monitors the binding of effector molecules to their target but also the subsequent effect on a biological system in vitro. This label-free and real-time method directly and simultaneously tracks mass and nanomechanical changes at the sensor interface using micro-cantilever technology. To prove the concept we measured lipid vesicle (approximately 748*10(6) Da) adsorption on the sensor interface followed by subsequent binding of the bee venom peptide melittin (2840 Da) to the vesicles. The results show the high dynamic range of the instrument and that measuring the mass and structural changes simultaneously allow a comprehensive discussion of molecular interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.