ArticleThe Plant cell2008
EFD Is an ERF transcription factor involved in the control of nodule number and differentiation in Medicago truncatula.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed.
- Molecular cartography of root nodule organogenesis: insights into the role of transcription factors.Plant molecular biology · 2026Review
- Hormone-modulated transcription factors orchestrating the root nodule symbiosis.Frontiers in plant science · 2026Review
- Genome-wide analysis of the AP2/ERF transcription factor superfamily in perennial ryegrass.BMC genomics · 2025Article
- Nodule-specificaBIOTECH · 2025Article
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- Complete genome sequence of the uniqueMicrobiology resource announcements · 2025Article
- Effect of Insecticides Imidacloprid and Alpha-Cypermethrin on the Development of Pea (Plants (Basel, Switzerland) · 2024Article
- Cellular basis of legume-rhizobium symbiosis.Plant communications · 2024Review
- Mapping the molecular landscape of Lotus japonicus nodule organogenesis through spatiotemporal transcriptomics.Nature communications · 2024Article
- Genome-wide identification, characterization, and evolutionary analysis of the barley TALE gene family and its expression profiles in response to exogenous hormones.Frontiers in plant science · 2024Article
- Comparison of the Formation of Plant-Microbial Interface inInternational journal of molecular sciences · 2023Article
- Comparative phylotranscriptomics reveals ancestral and derived root nodule symbiosis programmes.Nature plants · 2023Article
- It's Not You, It's Me: Medicago truncatula efd-1 Mutant Phenotype Depends on Rhizobium Symbiont.Plant & cell physiology · 2023Article
- Exogenously Applied Cytokinin Altered the Bacterial Release and Subsequent Stages of Nodule Development in PeaPlants (Basel, Switzerland) · 2023Article
- MtEFD and MtEFD2: Two transcription factors with distinct neofunctionalization in symbiotic nodule development.Plant physiology · 2022Article
- Genome-wide analysis of TALE superfamily in Triticum aestivum reveals TaKNOX11-A is involved in abiotic stress response.BMC genomics · 2022Article
- High-Resolution Translatome Analysis Reveals Cortical Cell Programs During Early Soybean Nodulation.Frontiers in plant science · 2022Article
- Large-Scale Integrative Analysis of Soybean Transcriptome Using an Unsupervised Autoencoder Model.Frontiers in plant science · 2022Article
- At the Root of Nodule Organogenesis: Conserved Regulatory Pathways Recruited by Rhizobia.Plants (Basel, Switzerland) · 2021Review
- Symbiotic Regulatory Genes Controlling Nodule Development inPlants (Basel, Switzerland) · 2020Review
22 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
Mechanisms regulating legume root nodule development are still poorly understood, and very few regulatory genes have been cloned and characterized. Here, we describe EFD (for ethylene response factor required for nodule differentiation), a gene that is upregulated during nodulation in Medicago truncatula. The EFD transcription factor belongs to the ethylene response factor (ERF) group V, which contains ERN1, 2, and 3, three ERFs involved in Nod factor signaling. The role of EFD in the regulation of nodulation was examined through the characterization of a null deletion mutant (efd-1), RNA interference, and overexpression studies. These studies revealed that EFD is a negative regulator of root nodulation and infection by Rhizobium and that EFD is required for the formation of functional nitrogen-fixing nodules. EFD appears to be involved in the plant and bacteroid differentiation processes taking place beneath the nodule meristem. We also showed that EFD activated Mt RR4, a cytokinin primary response gene that encodes a type-A response regulator. We propose that EFD induction of Mt RR4 leads to the inhibition of cytokinin signaling, with two consequences: the suppression of new nodule initiation and the activation of differentiation as cells leave the nodule meristem. Our work thus reveals a key regulator linking early and late stages of nodulation and suggests that the regulation of the cytokinin pathway is important both for nodule initiation and development.
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