Evidence map›Paper›PMID 18978013›Full record

ArticleNucleic acids research2009

Petabyte-scale innovations at the European Nucleotide Archive.

Guy Cochrane, Ruth Akhtar, James Bonfield, Lawrence Bower, Fehmi Demiralp, Nadeem Faruque, Richard Gibson, Gemma Hoad, Tim Hubbard, Christopher Hunter and 17 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Scientific Discovery Games for Biomedical Research.Annual review of biomedical data science · 2019
    Article
  7. ConvertingJournal of ginseng research · 2017
    Article
  8. Reconstructing 16S rRNA genes in metagenomic data.Bioinformatics (Oxford, England) · 2015
    Article
  9. Article
  10. Review
  11. Article
  12. Building models using Reactome pathways as templates.Methods in molecular biology (Clifton, N.J.) · 2013
    Article
  13. Review
  14. Article
  15. Article
  16. Aptamer Base: a collaborative knowledge base to describe aptamers and SELEX experiments.Database : the journal of biological databases and curation · 2012
    Article
  17. Enzyme informatics.Current topics in medicinal chemistry · 2012
    Review
  18. Article
  19. Article
  20. Methods and strategies for gene structure curation in WormBase.Database : the journal of biological databases and curation · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Guy CochraneEMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. cochrane@ebi.ac.uk
Ruth Akhtar
James Bonfield
Lawrence Bower
Fehmi Demiralp
Nadeem Faruque
Richard Gibson
Gemma Hoad
Tim Hubbard
Christopher Hunter
Mikyung Jang
Szilveszter Juhos
Rasko Leinonen
Steven Leonard
Quan Lin
Rodrigo Lopez
Dariusz Lorenc
Hamish McWilliam
Gaurab Mukherjee
Sheila Plaister
Rajesh Radhakrishnan
Stephen Robinson
Siamak Sobhany
Petra Ten Hoopen
Robert Vaughan
Vadim Zalunin
Ewan Birney

Funding

Wellcome Trust 077198Wellcome Trust 085532
6 · The paper itself

Abstract

Dramatic increases in the throughput of nucleotide sequencing machines, and the promise of ever greater performance, have thrust bioinformatics into the era of petabyte-scale data sets. Sequence repositories, which provide the feed for these data sets into the worldwide computational infrastructure, are challenged by the impact of these data volumes. The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/embl), comprising the EMBL Nucleotide Sequence Database and the Ensembl Trace Archive, has identified challenges in the storage, movement, analysis, interpretation and visualization of petabyte-scale data sets. We present here our new repository for next generation sequence data, a brief summary of contents of the ENA and provide details of major developments to submission pipelines, high-throughput rule-based validation infrastructure and data integration approaches.

Indexed as

Databases, Nucleic AcidInternetSequence AnalysisSystems Integration

Identifiers

PMID18978013
PMCPMC2686451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.