ReviewBriefings in functional genomics & proteomics2008
Using retroviruses as a mutagenesis tool to explore the zebrafish genome.
Review in Briefings in functional genomics & proteomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Zebrafish as a model for kidney function and disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Review
- Defects of CRB2 cause steroid-resistant nephrotic syndrome.American journal of human genetics · 2015Article
- Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- MLV integration site selection is driven by strong enhancers and active promoters.Nucleic acids research · 2014Article
- Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Conditional gene-trap mutagenesis in zebrafish.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Assaying hematopoiesis using zebrafish.Blood cells, molecules & diseases · 2013Review
- A large-scale zebrafish gene knockout resource for the genome-wide study of gene function.Genome research · 2013Article
- Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics.BMC cancer · 2013Article
- The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion.Nucleic acids research · 2013Article
- Article
- Zebrafish models for ectopic mineralization disorders: practical issues from morpholino design to post-injection observations.Frontiers in genetics · 2013Article
- Zebrafish: a model for the study of addiction genetics.Human genetics · 2012Review
- Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach.BMC genomics · 2011Article
- Investigating the genetics of visual processing, function and behaviour in zebrafish.Neurogenetics · 2011Review
- Zebrafish: a model system to study heritable skin diseases.The Journal of investigative dermatology · 2011Article
- Generating conditional mutations in zebrafish using gene-trap mutagenesis.Methods in cell biology · 2011Article
- A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3.Development (Cambridge, England) · 2010Article
- Host-microbe interactions in the developing zebrafish.Current opinion in immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We review different uses of the retroviral mutagenesis technology as the tool to manipulate the zebrafish genome. In addition to serving as a mutagen in a phenotype-driven forward mutagenesis screen as it was originally adapted for, retroviral insertional mutagenesis can also be exploited in reverse genetic approaches, delivering enhancer- and gene-trap vectors for the purpose of examining gene expression patterns and mutagenesis, making sensitized mutants amenable for chemical and genetic modifier screens, and producing gain-of-function mutations by epigenetically overexpressing the retroviral-inserted genes. From a technology point of view, we also summarize the recent advances in the high-throughput cloning of retroviral integration sites, a pivotal step toward identifying mutations. Lastly, we point to some potential directions that retroviral mutagenesis might take from the lessons of studying other model organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.