ArticleThe Journal of biological chemistry2008
Nonenzymatic RNA ligation in water.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The secret life of RNA and lipids.RNA biology · 2025Review
- Derivatization of Solid Supports Using a Carbamate-Linked Tether Containing a Disulfide Functional Group.Current protocols · 2025Article
- A Versatile Disulfide-Containing Solid-Support Strategy for 3'-Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis.Chemistry, an Asian journal · 2025Article
- Which came first: the chicken, the egg, or guanine?RNA (New York, N.Y.) · 2023Article
- Trinity of G-tetrads and origin of translation.Biology direct · 2022Article
- Lipid membranes modulate the activity of RNA through sequence-dependent interactions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Quadruplex World.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Novel Applications of Biocatalysis to Stereochemistry Determination of 2'3'-cGAMP Bisphosphorothioate (2'3'-cGACS omega · 2020Article
- Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides.RNA (New York, N.Y.) · 2020Article
- Copying of RNA Sequences without Pre-Activation.Angewandte Chemie (International ed. in English) · 2015Article
- Synergism and mutualism in non-enzymatic RNA polymerization.Life (Basel, Switzerland) · 2014Review
- Potential pitfalls in MALDI-TOF MS analysis of abiotically synthesized RNA oligonucleotides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.Cell reports · 2013Article
- May cyclic nucleotides be a source for abiotic RNA synthesis?Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Article
- A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- On the observable transition to living matter.Genomics, proteomics & bioinformatics · 2011Article
- The role of natural selection in the origin of life.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Review
- Generation of long RNA chains in water.The Journal of biological chemistry · 2009Article
- Non-enzymatic template-directed recombination of RNAs.International journal of molecular sciences · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the nonenzymatic ligation of RNA oligomers in water. Dimers and tetramers are formed in a time-, pH-, and temperature-dependent reaction. Ligation efficiency depends on oligonucleotide length and sequence and is strongly enhanced by adenine-based nucleotide cofactors. Ligation of short RNA fragments could have liberated the prebiotic polymerization systems from the thermodynamically demanding task of reaching a (pre)genetically meaningful size by stepwise addition of one precursor monomer at the time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.