ArticleCurrent biology : CB2008
PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.Molecular biology of the cell · 2026Article
- A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration.BMC genomics · 2023Article
- Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo.The Journal of cell biology · 2023Article
- A Scribble/Cdep/Rac pathway controls follower-cell crawling and cluster cohesion during collective border-cell migration.Developmental cell · 2022Article
- Synchronized, Spontaneous, and Oscillatory Detachment of Eukaryotic Cells: A New Tool for Cell Characterization and Identification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization.Current biology : CB · 2022Article
- Drosophila USP22/nonstop polarizes the actin cytoskeleton during collective border cell migration.The Journal of cell biology · 2021Article
- Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.Development (Cambridge, England) · 2019Article
- The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis.PloS one · 2019Article
- Rap1 GTPase promotes coordinated collective cell migration in vivo.Molecular biology of the cell · 2018Article
- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
- Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.Human molecular genetics · 2018Article
- Insulin signaling modulates border cell movement inDevelopment (Cambridge, England) · 2018Article
- Dendritic space-filling requires a neuronal type-specific extracellular permissive signal inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- PAR-1 promotes microtubule breakdown during dendrite pruning inThe EMBO journal · 2017Article
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
- Signaling through the G-protein-coupled receptor Rickets is important for polarity, detachment, and migration of the border cells in Drosophila.Developmental biology · 2016Article
- Pak4 Is Required during Epithelial Polarity Remodeling through Regulating AJ Stability and Bazooka Retention at the ZA.Cell reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMany cells that migrate during normal embryonic development or in metastatic cancer first detach from an epithelium. However, this step is often difficult to observe directly in vivo, and the mechanisms controlling the ability of cells to leave the epithelium are poorly understood. In addition, once cells detach, they must assume a migratory phenotype, involving changes in cytoskeletal and signaling dynamics. Drosophila border cells provide a model system in which a combination of forward genetics and live-cell imaging can allow researchers to investigate the cellular and molecular mechanisms of epithelial cell detachment and migration in vivo.
resultsWe identified the Drosophila homolog of the serine/threonine kinase PAR-1 (MARK/Kin1) in a screen for mutations that disrupt border cell migration. Previous studies identified two proteins, Apontic and Notch, that indirectly affect border cell detachment by regulating transcription of downstream targets. In contrast, PAR-1 directly modulates apical-basal polarity between border cells and epithelial cells to promote detachment. Furthermore, PAR-1, but not the apical polarity complex protein PAR-3, promotes the directionality of transient cell protrusions, which border cells require for sensing the chemoattractant gradient.
conclusionsWe conclude that PAR-1-dependent apical-basal polarity is required for proper detachment of migratory border cells from neighboring epithelial cells. Moreover, polarity controlled by PAR-1 influences the ability of migratory cells to sense direction, a critical feature of migration. Thus, this work reveals new insights into two distinct, but essential, steps of epithelial cell migration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.