ArticleCurrent biology : CB2008
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.
Article in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Optogenetic control of pheromone gradients and mating behavior in budding yeast.Life science alliance · 2025Article
- The roles of yeast formins and their regulators Bud6 and Bil2 in the pheromone response.Molecular biology of the cell · 2024Article
- Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.eLife · 2020Article
- Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission.Nature communications · 2020Article
- Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway.Molecular biology of the cell · 2020Article
- Crosstalk Between Pheromone Signaling and NADPH Oxidase Complexes Coordinates Fungal Developmental Processes.Frontiers in microbiology · 2020Article
- Oscillations and bistability in a model of ERK regulation.Journal of mathematical biology · 2019Article
- Article
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- Dynamics of Posttranslational Modification Systems: Recent Progress and Future Directions.Biophysical journal · 2018Review
- Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response.The Journal of biological chemistry · 2017Article
- Article
- Pycellerator: an arrow-based reaction-like modelling language for biological simulations.Bioinformatics (Oxford, England) · 2016Article
- Article
- Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Oscillation of p38 activity controls efficient pro-inflammatory gene expression.Nature communications · 2015Article
- Article
- Visualization of the spatial and temporal dynamics of MAPK signaling using fluorescence imaging techniques.The journal of physiological sciences : JPS · 2015Review
- Determinants of cell-to-cell variability in protein kinase signaling.PLoS computational biology · 2013Article
- Signalling by protein phosphatases and drug development: a systems-centred view.The FEBS journal · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Signal-transduction networks can display complex dynamic behavior such as oscillations in the activity of key components [1-6], but it is often unclear whether such dynamic complexity is actually important for the network's regulatory functions [7, 8]. Here, we found that the mitogen-activated protein kinase (MAPK) Fus3, a key regulator of the yeast mating-pheromone response, undergoes sustained oscillations in its phosphorylation and activation state during continuous pheromone exposure. These MAPK activity oscillations led to corresponding oscillations in mating-gene expression. Oscillations in MAPK activity and gene expression required the negative regulator of G protein signaling Sst2 and partially required the MAPK phosphatase Msg5. Peaks in Fus3 activation correlated with periodic rounds of cell morphogenesis, with each peak preceding the formation of an additional mating projection. Preventing projection formation did not eliminate MAPK oscillation, but preventing MAPK oscillation blocked the formation of additional projections. A mathematical model was developed that reproduced several features of the observed oscillatory dynamics. These observations demonstrate a role for MAPK activity oscillation in driving a periodic downstream response and explain how the pheromone signaling pathway, previously thought to desensitize after 1-3 hr, controls morphology changes that continue for a much longer time.
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Registered trials
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