Trial reportAmerican journal of obstetrics and gynecology2009
The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda.
Trial report in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02337179 (A Pilot Study to Introduce Male Circumcision), which is not on this map. Cited by 115 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR)
Who cites it
115 citing papers in PubMed, 8 syntheses or guidelines pooled it, 232 citations in OpenAlex.
- Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Critical evaluation of arguments opposing male circumcision: A systematic review.Journal of evidence-based medicine · 2019Pooled it
- Association between male circumcision and women's biomedical health outcomes: a systematic review.The Lancet. Global health · 2017Pooled it
- Pooled it
- Sexually transmitted diseases treatment guidelines, 2015.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2015Guideline
- Circumcision Status and Risk of HIV Acquisition during Heterosexual Intercourse for Both Males and Females: A Meta-Analysis.PloS one · 2015Pooled it
- The epidemiology of bacterial vaginosis in relation to sexual behaviour.BMC infectious diseases · 2010Pooled it
- Randomized controlled trials of interventions to prevent sexually transmitted infections: learning from the past to plan for the future.Epidemiologic reviews · 2010Pooled it
- Vaginal microbiota stability over 18 months in young student women in France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Trial
- Comparison of the penile microbiome in infant male circumcision: Mogen clamp versus Shangring.EBioMedicine · 2024Trial
- HIV shedding from male circumcision wounds in HIV-infected men: a prospective cohort study.PLoS medicine · 2015Trial
- Association between male circumcision and incidence of syphilis in men and women: a prospective study in HIV-1 serodiscordant heterosexual African couples.The Lancet. Global health · 2014Trial
- Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda.Sexually transmitted infections · 2014Trial
- Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria.mBio · 2013Trial
- The effect of medical male circumcision on urogenital Mycoplasma genitalium among men in Kisumu, Kenya.Sexually transmitted diseases · 2012Trial
- Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda.The Journal of infectious diseases · 2012Trial
- A behavioural intervention to reduce persistence of bacterial vaginosis among women who report sex with women: results of a randomised trial.Sexually transmitted infections · 2011Trial
- Circumcision of HIV-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in Rakai, Uganda.The Lancet. Infectious diseases · 2011Trial
- Topical penile microbicide use by men to prevent recurrent bacterial vaginosis in sex partners: a randomized clinical trial.Sexually transmitted diseases · 2011Trial
- Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda.Lancet (London, England) · 2011Trial
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveThe objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections. STUDY
designHuman immunodeficiency virus (HIV)-negative men enrolled in a trial were randomized to immediate or delayed circumcision (control arm). Genital symptoms, bacterial vaginosis (BV), and trichomonas were assessed in HIV-negative wives of married participants. Adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (CIs) were assessed by multivariable log-binomial regression, intent-to-treat analyses.
resultsA total of 783 wives of control and 825 wives of intervention arm men were comparable at enrollment. BV at enrollment was higher in control (38.3%) than intervention arm spouses (30.5%, P = .001). At 1 year follow-up, intervention arm wives reported lower rates of genital ulceration (adjPRR, 0.78; 95% CI, 0.63-0.97), but there were no differences in vaginal discharge or dysuria. The risk of trichomonas was reduced in intervention arm wives (adjPRR, 0.52; 95% CI, 0.05-0.98), as were the risks of any BV (adjPRR, 0.60; 95% CI, 0.38-0.94) and severe BV (prevalence risk ratios, 0.39; 95% CI, 0.24-0.64).
conclusionMale circumcision reduces the risk of ulceration, trichomonas, and BV in female partners.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.