Evidence map›Paper›PMID 18976706›Full record

ReviewEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2009

Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.

Laura Serra, Josep Doménech, Nicholas A Peppas

Abstract readReview
In one paragraph

Review in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. PEGylated insulin loaded complexation hydrogels for protected oral delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  10. Hydrogels for Mucosal Drug Delivery.ACS applied bio materials · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura SerraBiomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition Laboratories, University of Texas at Austin, Austin, TX 78712, USA.
Josep Doménech
Nicholas A Peppas

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMSR01GM056231 · NIGMS · PURDUE UNIVERSITY WEST LAFAYETTE · PI PEPPAS, NICHOLAS A · 1997 to 1999
–
NIBIB NIH HHS EB-000246-14NIBIB NIH HHS R01 EB000246NIGMS NIH HHS GM-56231-01
6 · The paper itself

Abstract

The goal of this critical review is to provide a critical analysis of the chain dynamics responsible for the action of micro- and nanoparticles of mucoadhesive biomaterials. The objective of using bioadhesive controlled drug delivery devices is to prolong their residence at a specific site of delivery, thus enhancing the drug absorption process. These mucoadhesive devices can protect the drug during the absorption process in addition to protecting it on its route to the delivery site. The major emphasis of recent research on mucoadhesive biomaterials has been on the use of adhesion promoters, which would enhance the adhesion between synthetic polymers and mucus. The use of adhesion promoters such as linear or tethered polymer chains is a natural result of the diffusional characteristics of adhesion. Mucoadhesion depends largely on the structure of the synthetic polymer gels used in controlled release applications.

Indexed as

Drug Delivery SystemsAdhesivenessAnimalsDelayed-Action PreparationsDrug CarriersHumansHydrogelsMicrospheresMucous MembraneNanoparticlesPolymersDelayed-Action PreparationsDrug CarriersHydrogelsPolymers

Identifiers

PMID18976706
PMCPMC2680154

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.