ArticleBMC evolutionary biology2008
Sex dependent imprinting effects on complex traits in mice.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.Cell metabolism · 2019Article
- Building a new research framework for social evolution: intralocus caste antagonism.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites.Genome biology and evolution · 2018Article
- Article
- Offspring genes indirectly influence sibling and maternal behavioural strategies over resource share.Proceedings. Biological sciences · 2017Article
- Gene interactions in the evolution of genomic imprinting.Heredity · 2014Review
- Review
- Review
- The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population.Journal of human genetics · 2014Article
- Sex-dependent genetic effects on immune responses to a parasitic nematode.BMC genomics · 2014Article
- Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects.BMC genetics · 2013Article
- The scope and strength of sex-specific selection in genome evolution.Journal of evolutionary biology · 2013Article
- Elevated expression of H19 and Igf2 in the female mouse eye.PloS one · 2013Article
- Empirical testing of hypotheses about the evolution of genomic imprinting in mammals.Frontiers in neuroanatomy · 2013Article
- The effect of parental allergy on childhood allergic diseases depends on the sex of the child.The Journal of allergy and clinical immunology · 2012Article
- Understanding the sexome: measuring and reporting sex differences in gene systems.Endocrinology · 2012Review
- Genotype-dependent responses to levels of sibling competition over maternal resources in mice.Heredity · 2012Article
- The evolution of gene expression and the transcriptome-phenotype relationship.Seminars in cell & developmental biology · 2012Review
- Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists.Biology of sex differences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGenomic imprinting is an epigenetic source of variation in quantitative traits that results from monoallelic gene expression, where commonly either only the paternally- or the maternally-derived allele is expressed. Imprinting has been shown to affect a diversity of complex traits in a variety of species. For several such quantitative traits sex-dependent genetic effects have been discovered, but whether imprinting effects also show such sex-dependence has yet to be explored. Moreover, theoretical work on the evolution of sex-dependent genomic imprinting effects makes specific predictions about the phenotypic patterns of such effects, which, however, have not been assessed empirically to date.
resultsUsing a genome-scan for loci affecting a set of complex growth and body composition traits from an intercross between two divergent mouse strains, we investigated possible sex-dependent imprinting effects. Our results demonstrate for the first time the existence of genomic imprinting effects that depend on sex and are not related to sex-chromosome effects. We detected a total of 13 loci on 11 chromosomes that showed significant differences between the sexes in imprinting effects. Most loci showed imprinting effects in only one sex, with eight imprinted effects found in males and six in females. One locus showed sex-dependent imprinting effects in both sexes for different traits. The absence of an imprinting effect in one sex was not necessarily indicative of the overall inactivity of the locus in that sex, as for several loci a significant additive or dominance effect was detected. Moreover, three loci exhibited significant additive effects in both sexes but their imprinting effect was restricted to one sex.
conclusionOur results clearly show that imprinting effects can be sex-dependent and also suggest that new candidate imprinted loci can be detected when taking account of sex-specific imprinting effects. However, predictions made about the evolution of sex-dependent imprinting effects and associated phenotypic patterns cannot be unequivocally supported at present and further research into the selection pressures applied to the strains of mice used in our study is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.