ArticleMolecular microbiology2008
Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Missing Pieces: The Role of Secretion Systems inBiomolecules · 2023Review
- Regulation of Effector Delivery by Type III Secretion Chaperone Proteins inFrontiers in microbiology · 2018Article
- Type III secretion systems: the bacterial flagellum and the injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate.The Journal of biological chemistry · 2013Article
- More evidence for secretion signals within the mRNA of type 3 secreted effectors.Journal of bacteriology · 2013Article
- Article
- Impact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion.Journal of bacteriology · 2011Article
- Regulated shift from helical to polar localization of Listeria monocytogenes cell wall-anchored proteins.Journal of bacteriology · 2011Article
- Extracellular secretion of a recombinant therapeutic peptide by Bacillus halodurans utilizing a modified flagellin type III secretion system.Microbial cell factories · 2011Article
- Remembering Malcolm J. Casadaban.Journal of bacteriology · 2010Article
- Multiple signals direct the assembly and function of a type 1 secretion system.Journal of bacteriology · 2010Article
- Application of a short, disordered N-terminal flagellin segment, a fully functional flagellar type III export signal, to expression of secreted proteins.Applied and environmental microbiology · 2010Article
- YopR impacts type III needle polymerization in Yersinia species.Molecular microbiology · 2010Article
- Accurate prediction of secreted substrates and identification of a conserved putative secretion signal for type III secretion systems.PLoS pathogens · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
Yersinia type III secretion machines transport substrate proteins into the extracellular medium or into the cytoplasm of host cells. Translational hybrids, involving genes that encode substrates as well as reporter proteins that otherwise cannot travel the type III pathway, identified signals that promote transport of effector Yops into host cells. Signals for the secretion of substrates into high calcium media were hitherto unknown. By exploiting attributes of translational hybrids between yopR, whose product is secreted, and genes that encode impassable proteins that jam the secretion machine, we isolated yopR mutations that abolish substrate recognition. Similar to effector Yops, an N-terminal or 5' signal in codons 1-11 is required to initiate YopR into the type III pathway. YopR secretion cannot be completed and translational hybrids cannot impose a block without a second signal, positioned at codons 131-149. Silent mutations in the second signal abrogate function and the phenotype of other mutations can be suppressed by secondary mutations predicted to restore base complementary in a 3' stem-loop structure of the yopR mRNA.
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