ArticleAmerican journal of human genetics1991
DNA typing and genetic mapping with trimeric and tetrameric tandem repeats.
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
217 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,158 citations in OpenAlex.
- Touch DNA Sampling Methods: Efficacy Evaluation and Systematic Review.International journal of molecular sciences · 2022Pooled it
- Screening of cerebral infarction-related genetic markers using a Cox regression analysis between onset age and heterozygosity at randomly selected short tandem repeat loci.Journal of thrombosis and thrombolysis · 2012Trial
- Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study.Bone marrow transplantation · 2000Trial
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- Artificial intelligence enables scale, consistency, and rigor in forensic identity inference.Croatian medical journal · 2026Review
- Genetic variation of 15 autosomal STR loci in the southern region population of KSA: A forensic DNA analysis study.Journal of Taibah University Medical Sciences · 2026Article
- Rethinking "Touch DNA": Why Forensic Science Should Move Away from Activity-Based Terms in Court.Forensic science, medicine, and pathology · 2026Article
- STRspy2.0: Unlocking the Potential of Long Reads for Forensic DNA Profiling.International journal of molecular sciences · 2026Article
- Unveiling the genetic tapestry of Kohistan: a population genetic analysis of autosomal STRs in a South Asian population.BMC genomics · 2026Article
- Forensic genetics in the omics era.Nature reviews. Genetics · 2026Review
- Review
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- Short tandem repeats - how microsatellites became the currency of forensic genetics.Nature reviews. Genetics · 2024Article
- Dense single nucleotide polymorphism testing revolutionizes scope and degree of certainty for source attribution in forensic investigations.Croatian medical journal · 2024Review
- The chromosomal characteristics of spontaneous abortion and its potential associated copy number variants and genes.Journal of assisted reproduction and genetics · 2024Article
- PCR in Forensic Science: A Critical Review.Genes · 2024Review
- From early methods for DNA diagnostics to genomes and epigenomes at high resolution during four decades - a personal perspective.Upsala journal of medical sciences · 2024Review
- DNA Profiling in Human Identification: From Past to Present.The Malaysian journal of medical sciences : MJMS · 2023Review
- CRISPR/Cas9-Mediated Knock-Out of theInternational journal of molecular sciences · 2023Article
157 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tandemly reiterated sequences represent a rich source of highly polymorphic markers for genetic linkage, mapping, and personal identification. Human trimeric and tetrameric short tandem repeats (STRs) were studied for informativeness, frequency, distribution, and suitability for DNA typing and genetic mapping. The STRs were highly polymorphic and inherited stably. A STR-based multiplex PCR for personal identification is described. It features fluorescent detection of amplified products on sequencing gels, specific allele identification, simultaneous detection of independent loci, and internal size standards. Variation in allele frequencies were explored for four U.S. populations. The three STR loci (chromosomes 4, 11, and X) used in the fluorescent multiplex PCR have a combined average individualization potential of 1/500 individuals. STR loci appear common, being found every 300-500 kb on the X chromosome. The combined frequency of polymorphic trimeric and tetrameric STRs could be as high as 1 locus/20 kb. The markers should be useful for genetic mapping, as they are sequence based, and can be multiplexed with the PCR. A method enabling rapid localization of STRs and determination of their flanking DNA sequences was developed, thus simplifying the identification of polymorphic STR loci. The ease by which STRs may be identified, as well as their genetic and physical mapping utility, give them the properties of useful sequence tagged sites (STSs) for the human genome initiative.
Indexed as
Identifiers
1897522PMC1683171W1541290060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.