Evidence map›Paper›PMID 18975108›Full record

ArticleNeuroscience and behavioral physiology2008

Intracerebral development of transplanted glioblastoma C6 cells in rats after preliminary exposure to neuropeptides and an MAPK inhibitor.

Ts S Tencheva, I R Panov

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroscience and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ts S TenchevaInstitute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
I R Panov
Bulgarian Academy of Sciences · BGLozenetz Hospital · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The invasive growth, proliferation, and transcriptional regulation of glioma C6 cells treated with endothelin-1 and PD98059, a specific inhibitor of ERK1/2 were studied. The proliferation of glioma C6 cells was assessed in different growth conditions by prior in vitro treatment with endothelin-1 followed by implantation into the brain. In vitro studies showed that PD98059 inhibited the proliferation of cultured glioma C6 cells and activated transcription factors E2F1 and Myc-Max. Endothelin-1 significantly increased the proliferation of glioma C6 cells. The model used in this study was experimental and may allow the specific features of the in vitro behavior of cultured invasive cells to be identified.

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsBrain NeoplasmsCell Line, TumorCell ProliferationCells, CulturedE2F1 Transcription FactorEndothelin-1FlavonoidsGlioblastomaMitogen-Activated Protein Kinase KinasesNeoplasm InvasivenessNeoplasm TransplantationProto-Oncogene Proteins c-mycRatsRats, Wistar2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneBasic-Leucine Zipper Transcription FactorsE2f1 protein, ratE2F1 Transcription FactorEndothelin-1FlavonoidsMitogen-Activated Protein Kinase KinasesMyc associated factor XMYC protein, humanProto-Oncogene Proteins c-myc

Identifiers

PMID18975108
OpenAlexW1976691765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.