ArticleClinical research in cardiology : official journal of the German Cardiac Society2009
Determinants of plasma NT-pro-BNP levels in patients with atrial fibrillation and preserved left ventricular ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 46 citations in OpenAlex.
- Impact of first-line antihypertensive drug class and intensity on NT-proBNP improvement and cardiovascular outcomes among hypertensive patients with pre-heart failure: findings from SPRINT trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
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- Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Associations between Dietary Phenolic Compounds and Biomarkers of Atrial Fibrillation Risk in Adults with Metabolic Syndrome: A Longitudinal Analysis.The Journal of nutrition · 2025Observational
- NT-proBNP for Heart Failure Screening in Primary Care in an Eastern European Country: What We Know and Proposed Steps.Epidemiologia (Basel, Switzerland) · 2025Article
- Setting the optimal threshold of NT-proBNP and BNP for the diagnosis of heart failure in patients over 75 years.ESC heart failure · 2024Observational
- NT-proBNP as a predictor of death and cardiovascular events in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2022Review
- One-Year Change in the HFrontiers in cardiovascular medicine · 2021Article
- Application of blood pre-albumin and NT-pro BNP levels in evaluating prognosis of elderly chronic heart failure patients.Experimental and therapeutic medicine · 2020Article
- Independent effect of atrial fibrillation on natriuretic peptide release.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Associates of an elevated natriuretic peptide level in stable heart failure patients: implications for targeted management.TheScientificWorldJournal · 2013Observational
- Prevalence, clinical phenotype, and outcomes associated with normal B-type natriuretic peptide levels in heart failure with preserved ejection fraction.The American journal of cardiology · 2012Article
- N-terminal pro-B-type natriuretic peptide level at long-term follow-up after atrial fibrillation ablation: a marker of reverse atrial remodelling and successful ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2012Article
- Relation of hs-CRP and BNP levels with the atrial spontaneous echo contrast and thrombi in permanent atrial fibrillation patients with different etiologies.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Diagnostic accuracy of NT-proBNP ratio (BNP-R) for early diagnosis of tachycardia-mediated cardiomyopathy: a pilot study.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Influence of acute and chronic myocardial loading conditions, function, structural changes and extracardiac factors on NT-proBNP in asymptomatic patients with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Factors associated with the development of atrial fibrillation in patients with rheumatic mitral stenosis.The international journal of cardiovascular imaging · 2010Article
- Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to investigate the clinical and echocardiographic determinants of plasma NT-pro-BNP levels in patients with atrial fibrillation (AF) and preserved left ventricular ejection fraction (LVEF).
methodsNT-pro-BNP levels were measured in 45 patients with paroxysmal AF, 41 patients with permanent AF and 48 controls.
resultsNT-pro-BNP levels were found significantly elevated in patients with paroxysmal (215+/-815 pg/ml) and permanent AF (1,086+/-835 pg/ml) in relation to control population (86.3+/-77.9 pg/ml) (P<0.001). According to the univariate linear regression analysis, age, hypertension, beta-blocker use, left atrial diameter (LAD), LVEF and AF status (paroxysmal or permanent or both) were significantly associated with NT-pro-BNP levels (P<0.05). In multiple linear regression analysis, LVEF (B coefficient: -53.030; CI: -95.738 to -10.322; P: 0.015) and LAD (B coefficient: 285.858; CI: 23.731-547.986; P: 0.033) were significant and independent determinants of NT-pro-BNP levels.
conclusionsPlasma NT-pro-BNP levels were significantly higher in patients with paroxysmal and permanent AF compared to those with sinus rhythm in the setting of preserved left ventricular systolic function. LVEF and LAD were independent predictors of NT-pro-BNP levels.
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