ArticlePloS one2008
Genetically-based olfactory signatures persist despite dietary variation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship.Chemical senses · 2025Article
- Partial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.Biology open · 2024Article
- Biodetection of an odor signature in white-tailed deer associated with infection by chronic wasting disease prions.PloS one · 2024Article
- Urinary VOCs as biomarkers of early stage lung tumour development in mice.Cancer biomarkers : section A of Disease markers · 2024Article
- Human scent as a first-line defense against disease.Scientific reports · 2023Article
- Hierarchical Elemental Odor Coding for Fine Discrimination Between Enantiomer Odors or Cancer-Characteristic Odors.Frontiers in behavioral neuroscience · 2022Review
- Differing Alterations of Odor Volatiles Among Pathogenic Stimuli.Chemical senses · 2021Article
- Individual Chemical Profiles in the Leach's Storm-Petrel.Journal of chemical ecology · 2020Article
- Article
- Volatile metabolomic signatures of rabies immunization in two mesocarnivore species.PLoS neglected tropical diseases · 2019Article
- Sharing an environment with sick conspecifics alters odors of healthy animals.Scientific reports · 2018Article
- Sniffer mice discriminate urine odours of patients with bladder cancer: A proof-of-principle study for non-invasive diagnosis of cancer-induced odours.Scientific reports · 2017Article
- Temporal Variation of White Rhino Dung Odours.Journal of chemical ecology · 2017Article
- GC-MS metabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of renal cell carcinoma patients.Journal of cellular and molecular medicine · 2017Article
- Reproductive endocrine patterns and volatile urinary compounds of Arctictis binturong: discovering why bearcats smell like popcorn.Die Naturwissenschaften · 2016Article
- Brain Injury Alters Volatile Metabolome.Chemical senses · 2016Article
- Alterations of the volatile metabolome in mouse models of Alzheimer's disease.Scientific reports · 2016Article
- Review
- Pyrazine analogues are active components of wolf urine that induce avoidance and freezing behaviours in mice.PloS one · 2013Article
- Avian influenza infection alters fecal odor in mallards.PloS one · 2013Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual mice have a unique odor, or odortype, that facilitates individual recognition. Odortypes, like other phenotypes, can be influenced by genetic and environmental variation. The genetic influence derives in part from genes of the major histocompatibility complex (MHC). A major environmental influence is diet, which could obscure the genetic contribution to odortype. Because odortype stability is a prerequisite for individual recognition under normal behavioral conditions, we investigated whether MHC-determined urinary odortypes of inbred mice can be identified in the face of large diet-induced variation. Mice trained to discriminate urines from panels of mice that differed both in diet and MHC type found the diet odor more salient in generalization trials. Nevertheless, when mice were trained to discriminate mice with only MHC differences (but on the same diet), they recognized the MHC difference when tested with urines from mice on a different diet. This indicates that MHC odor profiles remain despite large dietary variation. Chemical analyses of urinary volatile organic compounds (VOCs) extracted by solid phase microextraction (SPME) and analyzed by gas chromatography/mass spectrometry (GC/MS) are consistent with this inference. Although diet influenced VOC variation more than MHC, with algorithmic training (supervised classification) MHC types could be accurately discriminated across different diets. Thus, although there are clear diet effects on urinary volatile profiles, they do not obscure MHC effects.
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