ArticlePloS one2008
Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Genetic differentiation and local adaptation of the Japanese honeybee,Ecology and evolution · 2023Article
- Gut transcriptome of two bark beetle species stimulated with the same kairomones reveals molecular differences in detoxification pathways.Computational and structural biotechnology journal · 2022Article
- Thrice out of Asia and the adaptive radiation of the western honey bee.Science advances · 2021Article
- An Early Sensitive Period Induces Long-Lasting Plasticity in the Honeybee Nervous System.Frontiers in behavioral neuroscience · 2018Article
- Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.Scientific reports · 2017Article
- Identification and Expression Patterns of Putative Diversified Carboxylesterases in the Tea GeometridFrontiers in physiology · 2017Article
- Odor Experiences during Preimaginal Stages Cause Behavioral and Neural Plasticity in Adult Honeybees.Frontiers in behavioral neuroscience · 2016Article
- Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees.Scientific reports · 2015Article
- Genome-wide analysis of signatures of selection in populations of African honey bees (Apis mellifera) using new web-based tools.BMC genomics · 2015Article
- Genomic Analysis of Detoxification Supergene Families in the Mosquito Anopheles sinensis.PloS one · 2015Article
- Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub-lethal doses of the insecticide fipronil.Ecotoxicology (London, England) · 2014Article
- Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins.Journal of molecular neuroscience : MN · 2014Article
- Insecticide resistance mechanisms associated with different environments in the malaria vector Anopheles gambiae: a case study in Tanzania.Malaria journal · 2014Article
- Obligate mutualism within a host drives the extreme specialization of a fig wasp genome.Genome biology · 2013Article
- Neurexins.Genome biology · 2013Review
- Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.PloS one · 2012Article
- Functional phenotypic rescue of Caenorhabditis elegans neuroligin-deficient mutants by the human and rat NLGN1 genes.PloS one · 2012Article
- Fine-scale linkage mapping reveals a small set of candidate genes influencing honey bee grooming behavior in response to Varroa mites.PloS one · 2012Article
- Neurexins and neuroligins: recent insights from invertebrates.Molecular neurobiology · 2011Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate studies show neuroligins and neurexins are binding partners in a trans-synaptic cell adhesion complex, implicated in human autism and mental retardation disorders. Here we report a genetic analysis of homologous proteins in the honey bee. As in humans, the honeybee has five large (31-246 kb, up to 12 exons each) neuroligin genes, three of which are tightly clustered. RNA analysis of the neuroligin-3 gene reveals five alternatively spliced transcripts, generated through alternative use of exons encoding the cholinesterase-like domain. Whereas vertebrates have three neurexins the bee has just one gene named neurexin I (400 kb, 28 exons). However alternative isoforms of bee neurexin I are generated by differential use of 12 splice sites, mostly located in regions encoding LNS subdomains. Some of the splice variants of bee neurexin I resemble the vertebrate alpha- and beta-neurexins, albeit in vertebrates these forms are generated by alternative promoters. Novel splicing variations in the 3' region generate transcripts encoding alternative trans-membrane and PDZ domains. Another 3' splicing variation predicts soluble neurexin I isoforms. Neurexin I and neuroligin expression was found in brain tissue, with expression present throughout development, and in most cases significantly up-regulated in adults. Transcripts of neurexin I and one neuroligin tested were abundant in mushroom bodies, a higher order processing centre in the bee brain. We show neuroligins and neurexins comprise a highly conserved molecular system with likely similar functional roles in insects as vertebrates, and with scope in the honeybee to generate substantial functional diversity through alternative splicing. Our study provides important prerequisite data for using the bee as a model for vertebrate synaptic development.
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