ArticlePloS one2008
In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii.Scientific reports · 2023Article
- Discovery of New Microneme Proteins inFrontiers in veterinary science · 2021Article
- A Gene-Based Positive Selection Detection Approach to Identify Vaccine Candidates UsingFrontiers in genetics · 2018Article
- Production possibility frontiers in phototroph:heterotroph symbioses: trade-offs in allocating fixed carbon pools and the challenges these alternatives present for understanding the acquisition of intracellular habitats.Frontiers in microbiology · 2014Article
- Total and putative surface proteomics of malaria parasite salivary gland sporozoites.Molecular & cellular proteomics : MCP · 2013Article
- Galactose recognition by the apicomplexan parasite Toxoplasma gondii.The Journal of biological chemistry · 2012Article
- A novel PAN/apple domain-containing protein from Toxoplasma gondii: characterization and receptor identification.PloS one · 2012Article
- Article
- Cluster analysis identifies aminoacid compositional features that indicate Toxoplasma gondii adhesin proteins.Bioinformation · 2012Article
- Identification of tissue cyst wall components by transcriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoites.Eukaryotic cell · 2011Article
- Modulation of mouse macrophage proteome induced by Toxoplasma gondii tachyzoites in vivo.Parasitology research · 2011Article
- Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach.PloS one · 2011Article
- A systems biological view of intracellular pathogens.Immunological reviews · 2011Review
- Article
- Toxoplasma gondii transmembrane microneme proteins and their modular design.Molecular microbiology · 2010Article
- Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.Eukaryotic cell · 2010Article
- Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apicomplexan parasites, including the human pathogens Toxoplasma gondii and Plasmodium falciparum, employ specialized secretory organelles (micronemes, rhoptries, dense granules) to invade and survive within host cells. Because molecules secreted from these organelles function at the host/parasite interface, their identification is important for understanding invasion mechanisms, and central to the development of therapeutic strategies. Using a computational approach based on predicted functional domains, we have identified more than 600 candidate secretory organelle proteins in twelve apicomplexan parasites. Expression in transgenic T. gondii of eight proteins identified in silico confirms that all enter into the secretory pathway, and seven target to apical organelles associated with invasion. An in silico approach intended to identify possible host interacting proteins yields a dataset enriched in secretory/transmembrane proteins, including most of the antigens known to be engaged by apicomplexan parasites during infection. These domain pattern and projected interactome approaches significantly expand the repertoire of proteins that may be involved in host parasite interactions.
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