SynthesisMolecular & cellular proteomics : MCP2009
Predicting protein post-translational modifications using meta-analysis of proteome scale data sets.
Synthesis in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- Artificial intelligence in plant salt stress research: from predictive models to multi-omics integration.Journal of experimental botany · 2026Review
- Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells.Journal of cellular and molecular medicine · 2024Article
- Prediction of Protein Function from Tertiary Structure of the Active Site in Heme Proteins by Convolutional Neural Network.Biomolecules · 2023Article
- The Okur-Chung Neurodevelopmental Syndrome Mutation CK2Frontiers in molecular biosciences · 2022Article
- Large-scale Identification and Time-course Quantification of Ubiquitylation Events During Maize Seedling De-etiolation.Genomics, proteomics & bioinformatics · 2019Article
- Deep Protein Methylation Profiling by Combined Chemical and Immunoaffinity Approaches Reveals Novel PRMT1 Targets.Molecular & cellular proteomics : MCP · 2019Article
- Lysine Acetylation is an Important Post-Translational Modification that Modulates Heat Shock Response in the Sea CucumberInternational journal of molecular sciences · 2019Article
- Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis.The Journal of biological chemistry · 2019Article
- Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique.Nature communications · 2019Article
- Article
- Precision Profiling of the Cardiovascular Post-Translationally Modified Proteome: Where There Is a Will, There Is a Way.Circulation research · 2018Review
- Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets ofMolecular & cellular proteomics : MCP · 2018Article
- Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model.American journal of physiology. Heart and circulatory physiology · 2017Article
- Cushing's syndrome mutant PKAFEBS letters · 2017Article
- N-linked glycosite profiling and use of Skyline as a platform for characterization and relative quantification of glycans in differentiating xylem of Populus trichocarpa.Analytical and bioanalytical chemistry · 2017Article
- Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A homology-based pipeline for global prediction of post-translational modification sites.Scientific reports · 2016Article
- Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics.Molecular & cellular proteomics : MCP · 2016Article
- Article
- Uncovering Phosphorylation-Based Specificities through Functional Interaction Networks.Molecular & cellular proteomics : MCP · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Protein post-translational modifications are an important biological regulatory mechanism, and the rate of their discovery using high throughput techniques is rapidly increasingly. To make use of this wealth of sequence data, we introduce a new general strategy designed to predict a variety of post-translational modifications in several organisms. We used the motif-x program to determine phosphorylation motifs in yeast, fly, mouse, and man and lysine acetylation motifs in man. These motifs were then scanned against proteomic sequence data using a newly developed tool called scan-x to globally predict other potential modification sites within these organisms. 10-fold cross-validation was used to determine the sensitivity and minimum specificity for each set of predictions, all of which showed improvement over other available tools for phosphoprediction. New motif discovery is a byproduct of this approach, and the phosphorylation motif analyses provide strong evidence of evolutionary conservation of both known and novel kinase motifs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.