Trial reportThe Journal of allergy and clinical immunology2008
Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing.
Trial report in The Journal of allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00319488 (Childhood Asthma Research and Education), which is not on this map. Cited by 81 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Childhood Asthma Research and Education (CARE) Network Trial - Acute Intervention Management Strategies (AIMS)
Who cites it
81 citing papers in PubMed, 11 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- A meta-analysis of montelukast for recurrent wheeze in preschool children.European journal of pediatrics · 2017Pooled it
- Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children.The Cochrane database of systematic reviews · 2015Pooled it
- Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults.The Cochrane database of systematic reviews · 2015Pooled it
- Leukotriene inhibitors for bronchiolitis in infants and young children.The Cochrane database of systematic reviews · 2015Pooled it
- Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma.The Cochrane database of systematic reviews · 2013Pooled it
- Glucocorticoids for acute viral bronchiolitis in infants and young children.The Cochrane database of systematic reviews · 2013Pooled it
- Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults.The Cochrane database of systematic reviews · 2013Pooled it
- Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children.The Cochrane database of systematic reviews · 2012Pooled it
- Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children.The Cochrane database of systematic reviews · 2012Pooled it
- Asthma and other recurrent wheezing disorders in children (chronic).BMJ clinical evidence · 2012Pooled it
- Addition of a nutraceutical to montelukast or inhaled steroid in the treatment of wheezing during COVID-19 pandemic: a multicenter, open-label, randomized controlled trial.Acta bio-medica : Atenei Parmensis · 2022Trial
- Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.The journal of allergy and clinical immunology. In practice · 2019Trial
- Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations.The New England journal of medicine · 2018Trial
- Individualized therapy for persistent asthma in young children.The Journal of allergy and clinical immunology · 2016Trial
- Trial
- Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial.The Lancet. Respiratory medicine · 2014Trial
- The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing.The Journal of allergy and clinical immunology · 2014Trial
- Daily or intermittent budesonide in preschool children with recurrent wheezing.The New England journal of medicine · 2011Trial
- Short term efficacy of nebulized beclomethasone in mild-to-moderate wheezing episodes in pre-school children.Italian journal of pediatrics · 2011Trial
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundAcute wheezing illnesses in preschoolers require better management strategies to reduce morbidity.
objectivesWe sought to examine the effectiveness of episodic use of an inhaled corticosteroid and a leukotriene receptor antagonist in preschoolers with intermittent wheezing.
methodsIn a randomized, double-blind, placebo-controlled 12-month trial, 238 children aged 12 to 59 months with moderate-to-severe intermittent wheezing received 7 days of either budesonide inhalation suspension (1 mg twice daily), montelukast (4 mg daily), or placebo in addition to albuterol with each identified respiratory tract illness (RTI). Proportion of episode-free days (EFDs) during the 12-month trial was the primary outcome.
resultsThe 3 treatment groups did not differ in proportions of EFDs, with adjusted mean EFDs of 76% (95% CI, 70% to 81%) for budesonide, 73% (95% CI, 66% to 79%) for montelukast, and 74% (95% CI, 65% to 81%) for conventional therapy (P = .66). The 3 groups did not differ in oral corticosteroid use, health care use, quality of life, or linear growth. However, during RTIs, budesonide and montelukast therapy led to modest reductions in trouble breathing (38% [P = .003] and 37% [P = .003], respectively) and interference with activity scores (32% [P = .01] and 40% [P = .001], respectively) that were most evident in those with positive asthma predictive indices.
conclusionsIn preschool children with moderate-to-severe intermittent wheezing, episodic use of either budesonide or montelukast early in RTIs, when added to albuterol, did not increase the proportion of EFDs or decrease oral corticosteroid use over a 12-month period. However, indicators of severity of acute illnesses were reduced, particularly in children with positive asthma predictive indices.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.