ReviewCurrent pain and headache reports2008
New theories in the pathogenesis of menstrual migraine.
Review in Current pain and headache reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Hypothalamic and sex-related hormones in migraine.The journal of headache and pain · 2026Review
- Evaluating Cerebral Blood Flow among Patients Experiencing Premenstrual Syndrome with Headache using Duplex Ultrasonography.Current medical imaging · 2025Article
- The effects of estradiol levels on crossmodal perception: a study on the sound induced flash illusion in healthy and menstrually related migraine individuals.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Estradiol Treatment Enhances Behavioral and Molecular Changes Induced by Repetitive Trigeminal Activation in a Rat Model of Migraine.Biomedicines · 2022Article
- Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway.Brain sciences · 2022Article
- Comparison Between Menstrual Migraine and Menstrual-Unrelated Migraine in Women Attending Gynecology Clinics.Cureus · 2020Article
- Management of Menstrual Migraine.Current neurology and neuroscience reports · 2020Review
- Evolution, the Menstrual Cycle, and Theoretical Overreach.Perspectives on psychological science : a journal of the Association for Psychological Science · 2020Article
- Male and female sex hormones in primary headaches.The journal of headache and pain · 2018Review
- Sex differences and hormonal modulation of deep tissue pain.Frontiers in neuroendocrinology · 2013Review
- Comorbidity in perimenstrual migraine.Current pain and headache reports · 2012Review
- Management of menstrual migraine: a review of current abortive and prophylactic therapies.Current pain and headache reports · 2010Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormonal and nonhormonal factors play a role in the pathophysiology of menstrual migraine, but estrogen withdrawal appears to be the most potent of these factors. It is postulated that estrogen withdrawal directly enhances excitability of trigeminal afferents, modulates the synthesis of neuropeptides, activates/deactivates specific neurotransmitter systems, and influences the function of microglia. These changes could activate and/or sensitize the trigeminal system and increase the likelihood of migraine headache during perimenstrual time periods. Three new theories are advanced in this article to explain the pathophysiology of menstrual migraine. Only through an understanding of the mechanisms involved in menstrual migraine can we gain insight into the management of this severe and debilitating form of migraine headache.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.