ArticleThe Biochemical journal2009
The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
Article in The Biochemical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.Redox biology · 2026Review
- Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly.International journal of molecular sciences · 2021Review
- The Effect of tRNAInternational journal of molecular sciences · 2021Article
- The Neurobiology of Selenium: Looking Back and to the Future.Frontiers in neuroscience · 2021Review
- Article
- Ribosome profiling of selenoproteinsThe Journal of biological chemistry · 2019Article
- Selenocysteine β-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme.Antioxidants (Basel, Switzerland) · 2019Review
- The modified base isopentenyladenosine and its derivatives in tRNA.RNA biology · 2017Review
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Physiological reviews · 2016Review
- Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.The Journal of biological chemistry · 2014Article
- Deletion of selenoprotein M leads to obesity without cognitive deficits.The Journal of biological chemistry · 2013Article
- Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation.Physiological genomics · 2013Article
- Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.Carcinogenesis · 2013Article
- Understanding selenoprotein function and regulation through the use of rodent models.Biochimica et biophysica acta · 2012Review
- Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.The Journal of biological chemistry · 2011Article
- Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development.Molecules (Basel, Switzerland) · 2009Review
- The human selenoproteome: recent insights into functions and regulation.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
STAF [Sec (selenocysteine) tRNA gene transcription activating factor] is a transcription activating factor for a number of RNA Pol III- and RNA Pol II-dependent genes including the Trsp [Sec tRNA gene], which in turn controls the expression of all selenoproteins. Here, the role of STAF in regulating expression of Sec tRNA and selenoproteins was examined. We generated transgenic mice expressing the Trsp transgene lacking the STAF-binding site and made these mice dependent on the transgene for survival by removing the wild-type Trsp. The level of Sec tRNA was unaffected or slightly elevated in heart and testis, but reduced approximately 60% in liver and kidney, approximately 70% in lung and spleen and approximately 80% in brain and muscle compared with the corresponding organs in control mice. Moreover, the ratio of the two isoforms of Sec tRNA that differ by methylation at position 34 (Um34) was altered significantly, and the Um34-containing form was substantially reduced in all tissues examined. Selenoprotein expression in these animals was most affected in tissues in which the Sec tRNA levels were most severely reduced. Importantly, mice had a neurological phenotype strikingly similar to that of mice in which the selenoprotein P gene had been removed and their life span was substantially reduced. The results indicate that STAF influences selenoprotein expression by enhancing Trsp synthesis in an organ-specific manner and by controlling Sec tRNA modification in each tissue examined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.