ReviewMass spectrometry reviews
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments.
Review in Mass spectrometry reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- No evidence of differential impact of sunflower and rapeseed oil on biomarkers of coronary artery disease or chronic kidney disease in healthy adults with overweight and obesity: result from a randomised control trial.European journal of nutrition · 2022Trial
- Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.Journal of the American Society of Nephrology : JASN · 2015Trial
- Mass Spectrometry Advancements and Applications for Biomarker Discovery, Diagnostic Innovations, and Personalized Medicine.International journal of molecular sciences · 2024Review
- Recent progress in mass spectrometry-based urinary proteomics.Clinical proteomics · 2024Review
- Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS.Molecules (Basel, Switzerland) · 2021Article
- Indication of high lipid content in epithelial-mesenchymal transitions of breast tissues.Scientific reports · 2021Article
- Peptidomics and Capillary Electrophoresis.Advances in experimental medicine and biology · 2021Article
- Recent trends of capillary electrophoresis-mass spectrometry in proteomics research.Mass spectrometry reviews · 2019Review
- Profiling of Amino Acids in Urine Samples of Patients Suffering from Inflammatory Bowel Disease by Capillary Electrophoresis-Mass Spectrometry.Molecules (Basel, Switzerland) · 2019Article
- Middle-down approach: a choice to sequence and characterize proteins/proteomes by mass spectrometry.RSC advances · 2018Review
- The Use of a 3D-Printed Microfluidic Device and Pressure Mobilization for Integrating Capillary Electrophoresis with Electrochemical Detection.Electroanalysis · 2018Article
- Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction.Journal of the American Society of Hypertension : JASH · 2018Article
- Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease.Scientific reports · 2018Article
- Metabolomics-A Promising Approach to Pituitary Adenomas.Frontiers in endocrinology · 2018Review
- Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus.Lupus · 2018Article
- Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome.Environment international · 2017Review
- Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups.Scientific reports · 2017Article
- Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency?International journal of chronic obstructive pulmonary disease · 2017Article
- The Promise of Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease.Current diabetes reports · 2016Review
- The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Proteome analysis has emerged as a powerful technology to decipher biological processes. One of the main goals is to discover biomarkers for diseases from tissues and body fluids. However, the complexity and wide dynamic range of protein expression present an enormous challenge to separation technologies and mass spectrometry (MS). In this review, we examine the limitations of proteomics, and aim towards the definition of the current key prerequisites. We focus on capillary electrophoresis coupled to mass spectrometry (CE-MS), because this technique continues to show great promise. We discuss CE-MS from an application point of view, and evaluate its merits and vices for biomarker discovery and clinical applications. Finally, we present several examples on the use of CE-MS to determine urinary biomarkers and implications for disease diagnosis, prognosis, and therapy evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.