ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2008
Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: suggestive linkage to 3q13.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth.Development and psychopathology · 2021Article
- DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.Brain and behavior · 2018Article
- Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.Molecular psychiatry · 2016Article
- Sex differences in ADHD symptom severity.Journal of child psychology and psychiatry, and allied disciplines · 2015Article
- Neuropsychological and dimensional behavioral trait profiles in Costa Rican ADHD sib pairs: Potential intermediate phenotypes for genetic studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Genetic linkage analysis in the age of whole-genome sequencing.Nature reviews. Genetics · 2015Review
- Recognition of facial emotion and affective prosody in children with ASD (+ADHD) and their unaffected siblings.European child & adolescent psychiatry · 2014Article
- The genetics of attention deficit/hyperactivity disorder in adults, a review.Molecular psychiatry · 2012Review
- Associations between psychiatric comorbidities and sleep disturbances in children with attention-deficit/hyperactivity disorder.Journal of developmental and behavioral pediatrics : JDBP · 2012Article
- Teaching neuroinformatics with an emphasis on quantitative locus analysis.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2012Article
- Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies.European archives of psychiatry and clinical neuroscience · 2011Review
- Potential cognitive endophenotypes in multigenerational families: segregating ADHD from a genetic isolate.Attention deficit and hyperactivity disorders · 2011Article
- Epigenetics in Developmental Disorder: ADHD and Endophenotypes.Journal of genetic syndromes & gene therapy · 2011Article
- A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits.PloS one · 2011Article
- Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
- Developmental and genetic influences on prefrontal function in adolescents: a longitudinal twin study of WCST performance.Neuroscience letters · 2010Article
- Molecular genetics of attention-deficit/hyperactivity disorder: an overview.European child & adolescent psychiatry · 2010Review
- Teaching bioinformatics and neuroinformatics by using free web-based tools.CBE life sciences education · 2010Article
- DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics.Pharmacogenomics and personalized medicine · 2010Article
- Neurocognitive impairment in unaffected siblings of youth with bipolar disorder.Psychological medicine · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Family and twin studies suggest that a range of neurocognitive traits index the inherited liability to ADHD; however, the utility of such measures as endophenotypes in molecular genetic studies remains largely untested. The current article examined whether the inclusion of neurocognitive measures in a genomewide linkage analysis of ADHD could aid in identifying QTL linked to the behavioral symptoms of the condition. Data were from an affected sibling pair linkage study of DSM-IV ADHD conducted at Massachusetts General Hospital. The sample included 1,212 individuals from 271 families. ADHD symptoms were assessed with the K-SADS-E. The neurocognitive battery included Wechsler Intelligence Scales subtests, the Stroop, the Wisconsin Card Sorting Test (WCST), the Rey-Osterreith Complex Figure, a working memory CPT, the CVLT and WRAT-III subscales. Evidence for linkage was assessed using a simulation-based method that combines information from univariate analyses into the equivalent of a multivariate test. After correction for multiple trait testing, a region on chromosome 3q13 showed suggestive linkage to all neurocognitive traits examined and inattention symptoms of ADHD. The second highest peak occurred on 22q12 but showed linkage to a single subscale of the WCST. In univariate analysis, this region retained criteria for suggestive linkage to this measure after correction for multiple trait testing. Our primary findings raise the possibility that one or more genes on 3q13 influence neurocognitive functions and behavioral symptoms of inattention. Overall, these data support the utility of neurocognitive traits as ADHD endophenotypes, but also highlight their limited genetic overlap with the disorder.
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