ArticleInternational journal of cancer2009
Marine n-3 and saturated fatty acids in relation to risk of colorectal cancer in Singapore Chinese: a prospective study.
Article in International journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 8 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Inverse association between eicosapentaenoic acid and incident colorectal cancer: a dose-response meta-analysis of twenty-six independent prospective cohorts.European journal of nutrition · 2025Pooled it
- Dietary intake and tissue biomarkers of omega-6 fatty acids and risk of colorectal cancer in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.Nutrition & diabetes · 2025Pooled it
- Dietary fatty acids and colorectal cancer risk in men: A report from the Shanghai Men's Health Study and a meta-analysis.International journal of cancer · 2021Pooled it
- N-6 Polyunsaturated Fatty Acids and Risk of Cancer: Accumulating Evidence from Prospective Studies.Nutrients · 2020Pooled it
- Omega-3 PUFA intake and the risk of digestive system cancers: A meta-analysis of observational studies.Medicine · 2020Pooled it
- Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2018Pooled it
- Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies.PloS one · 2015Pooled it
- Is dietary fat associated with the risk of colorectal cancer? A meta-analysis of 13 prospective cohort studies.European journal of nutrition · 2011Pooled it
- Fatty Acid Heterogeneity in Colorectal Cancer: From Food Matrices to Targeted Interventions.Cancers · 2026Review
- Dietary and other lifestyle factors and their influence on non-communicable diseases in the Western Pacific region.The Lancet regional health. Western Pacific · 2024Review
- Serum Saturated Fatty Acids including Very Long-Chain Saturated Fatty Acids and Colorectal Cancer Risk among Chinese Population.Nutrients · 2023Article
- On optimal two-stage testing of multiple mediators.Biometrical journal. Biometrische Zeitschrift · 2022Article
- Dietary fat and fatty acids in relation to risk of colorectal cancer.European journal of nutrition · 2022Article
- Pleiotropic roles of FXR in liver and colorectal cancers.Molecular and cellular endocrinology · 2022Article
- Dietary Fat Intake andNutrients · 2022Article
- Association between dietary fat intake and colorectal cancer: A multicenter case-control study in Iran.Frontiers in nutrition · 2022Article
- Use of Exopolysaccharide-Synthesizing Lactic Acid Bacteria and Fat Replacers for Manufacturing Reduced-Fat Burrata Cheese: Microbiological Aspects and Sensory Evaluation.Microorganisms · 2020Article
- Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice.Nutrients · 2019Article
- The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer risk.Menopause (New York, N.Y.) · 2019Observational
- High olive oil diets enhance cervical tumour growth in mice: transcriptome analysis for potential candidate genes and pathways.Lipids in health and disease · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Experimental data support multiple roles for fatty acids in colorectal carcinogenesis. We examined dietary fatty acids and incidence of colorectal cancer, and evaluated effect modification by sex and stage of disease among a population-based cohort of 61,321 Singapore Chinese that was established between 1993 and 1998. As of December 31, 2005, 961 incident colorectal cancers were diagnosed. Presented hazard ratios (HRs) are for highest versus lowest quartiles with adjustment for potential confounders. Among women, we observed a dose-dependent, positive association between saturated fat and localized colorectal cancer (Dukes A or B) [(HR=1.69, 95% confidence interval (CI)=1.08-2.63, p for trend=0.01)]. No such associations were noted in men (p for interaction by sex=0.04). Marine n-3 polyunsaturated fatty acid (PUFA) intake was positively associated with advanced disease (Dukes C or D) (HR=1.33, 95% CI=1.05-1.70, p for trend=0.01), regardless of sex. The association with marine n-3 PUFAs was strongest among those with the shortest (<or=5 years) duration of follow-up (HR=1.49, 95% CI=1.00-2.21, p for trend=0.04). In contrast, we observed a small, albeit imprecise, inverse association with marine n-3 PUFAs for localized colorectal cancer among those with the longest duration of follow-up (>10 years) (HR=0.62, 95% CI=0.29-1.34, p for trend=0.55). Our findings suggest that subtypes of fatty acids may differentially influence risk of colorectal cancer of a specified stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.