SynthesisYonsei medical journal2008
Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies.
Synthesis in Yonsei medical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis.Scientific reports · 2025Pooled it
- High phosphorus intake and gut-related parameters - results of a randomized placebo-controlled human intervention study.Nutrition journal · 2018Trial
- Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations.Cancer prevention research (Philadelphia, Pa.) · 2016Trial
- Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- Gender modifies the effect of ursodeoxycholic acid in a randomized controlled trial in colorectal adenoma patients.Cancer prevention research (Philadelphia, Pa.) · 2009Trial
- Physical activity as a determinant of fecal bile acid levels.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- Novel bacteriumGut microbes · 2026Article
- Gallbladder disease and colorectal cancer: a two-sample bidirectional Mendelian randomization study.Discover oncology · 2026Article
- State of omics-based microbial diagnostics of CRC.Gut microbes · 2025Review
- Comprehensive evaluation and progress of colorectal cancer screening methods.Gut pathogens · 2025Review
- The cancer microbiome.Advances in clinical chemistry · 2025Review
- Article
- Review
- Heterogeneity and lyophilization comparison of stool processing for gastrointestinal bile acid measurement by LC-MS/MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2023Article
- Bile acid distributions, sex-specificity, and prognosis in colorectal cancer.Biology of sex differences · 2022Article
- Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis.Cancer science · 2022Article
- Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients.Gut pathogens · 2021Article
- Nasobiliary drainage prior to surgical biliary diversion in progressive familial intrahepatic cholestasis type II.European journal of pediatrics · 2020Article
- Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study.Journal of the National Cancer Institute · 2020Article
- Role of bile acids in colon carcinogenesis.World journal of clinical cases · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo provide a systematic review with meta-analysis for addressing the relationship between fecal bile acids (FBAs) and colorectal cancer. MATERIALS AND
methodsElectronic databases were searched for all observational studies that examined the relationship between FBAs and colorectal cancer or adenoma, and calculated weighted mean difference (WMD) and 95% confidence interval (CI). Publication bias was assessed with funnel plot.
resultsTwenty case-control or cohort studies were identified. All studies were pooled to assess the relationship between total FBAs and cancer/adenoma of the large bowel, however, no association was seen (WMD 0.61mg/g freeze-dried feces; 95% CI: -0.35-1.57). Significantly increased concentration of chenodeoxycholic acid (CDCA) was seen while pooling to assess the relationship between CDCA and cancer/adenoma of the large bowel (WMD 0.13 mg/g freeze-dried feces; 95% CI: 0.01-0.25), especially for colorectal cancer (WMD 0.28mg/g freeze-dried feces; 95% CI: 0.10-0.46). However, no significant differences in deoxycholic acid (DCA), lithocholic acid (LCA), and primary and secondary bile acids, were seen between patients with cancer and patients with matched controls regardless of fixed and random effects models.
conclusionCDCA might play a role in the etiology of colorectal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.