ArticleDigestive diseases and sciences2009
The effect of iNOS inhibitors and hyperbaric oxygen treatment in a rat model of experimental colitis.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Hyperbaric oxygen therapy alleviates intestinal and brain damage in experimental necrotizing enterocolitis.Medical gas research · 2025Article
- The role of hyperbaric oxygen therapy in the treatment of radiation lesions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury.Neuropsychiatric disease and treatment · 2016Review
- iNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis.Acta orthopaedica · 2015Article
- Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats.Medical gas research · 2015Article
- Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes.Journal of physiology and biochemistry · 2012Article
- Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis.Medical gas research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOur aim was to investigate the effectiveness of aminoguanidine (AMG), an inducible nitric oxide synthase inhibitor, and hyperbaric oxygen (HBO) treatment in an experimental colitis model.
methodsWe induced colitis in rats. In the control group, we applied 2 ml serum physiologic intraperitoneally for 7 days. In the HBO group, 100% oxygen at 2.4 atm pressure was applied for 7 days. In the AMG group, 100 mg/kg AMG was applied intraperitoneally for 7 days. In the HBO + AMG group, HBO and AMG were applied, respectively. At the end of 7 days, rats were sacrificed and the distal 10 cm part of colon was examined macro- and microscopically.
resultsSeverity of colitis and NO activities were reduced by AMG, HBO, and HBO + AMG application. There was histologically significant improvement, especially in the HBO + AMG group.
conclusionsBoth HBO and AMG were significantly effective in preventing weight loss, reducing NO activities, and severity of colitis, when comparing HBO and AMG separately.
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