Evidence map›Paper›PMID 18972186›Full record

ArticleInternational journal of hematology2008

Establishment of CD5 and CD10 double-positive mature B-cell line, WILL1, showing complex 8q24 translocation involving 14q32 and 6q27.

Shima Uneda, Minako Gotoh, Takashi Sonoki, Kazuhiro Nishida, Yasushi Nakamura, Miwa Kurimoto, Nobuyoshi Hanaoka, Hiroshi Matsuoka, Masafumi Taniwaki, Hideki Nakakuma

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In one paragraph

Article in International journal of hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shima UnedaDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
Minako GotohDepartment of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Takashi SonokiDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan. sonoki@wakayama-med.ac.jp.
Kazuhiro NishidaDepartment of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yasushi NakamuraDepartment of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama, Japan.
Miwa KurimotoDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
Nobuyoshi HanaokaDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
Hiroshi MatsuokaDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
Masafumi TaniwakiDepartment of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hideki NakakumaDepartment of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.
Wakayama Medical University · JPKyoto Prefectural University of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We established a novel mature B-cell line from a CD5 and CD10 double-positive diffuse large B-cell lymphoma patient, designated as WILL1. WILL1 cells were positive for CD5, CD10, CD19, and CD20. Spectral karyotype (SKY) analysis revealed chromosome 8 signals on 6q27 as well as 14q32. Fluorescence in situ hybridization (FISH) analysis suggested that a translocation break occurred outside the immunoglobulin heavy chain (IGH) gene on 14q32. Moreover, fusion signals of IGH and C-MYC probes were detected on the derivative 6 and derivative 14 chromosomes. Southern blot analysis using a C-MYC exon II fragment failed to detect rearrangement, suggesting that the 8q24 breakpoints lay far up- or downstream of the C-MYC gene. WILL1 is a useful tool to analyze the pathogenesis of CD5 and CD10 double-positive diffuse large B-cell lymphoma, and for molecular cloning of the unique translocation breakpoints of 14q32 and 8q24 and a novel gene on 6q27.

Indexed as

CD5 AntigensNeprilysinTranslocation, GeneticAged, 80 and overAsian PeopleB-LymphocytesCell Line, TumorChromosomes, HumanHumansImmunoglobulin Heavy ChainsJapanLymphoma, Large B-Cell, DiffuseMaleOncogene Proteins, FusionProto-Oncogene Proteins c-mycCD5 AntigensImmunoglobulin Heavy ChainsMYC protein, humanNeprilysinOncogene Proteins, FusionProto-Oncogene Proteins c-myc

Identifiers

PMID18972186
OpenAlexW2087001477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.