ArticleObesity surgery2009
Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content.
Article in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2013Trial
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- Does bariatric surgery improve adipose tissue function?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016Review
- Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese.BBA clinical · 2016Article
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- Morbidly "Healthy" Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia.Obesity surgery · 2015Article
- Hepatic Steatosis as a Marker of Metabolic Dysfunction.Nutrients · 2015Review
- Review
- Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.Hepatology (Baltimore, Md.) · 2010Review
- Article
- Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosis.Obesity surgery · 2009Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe types and sources of lipid deposition in the liver of most patients with morbid obesity, as well as the effects of bariatric surgery, are discussed.
methodsIn 26 patients with morbid obesity who underwent bariatric surgery, we analyzed different kinds of lipids and hepatic lipase (HL) from both plasma and liver biopsies performed 12-18 months after surgery.
resultsThe HL activity and HL-mRNA in morbidly obese (MO) livers were high (258 +/- 17 mU/g, and 4.5-fold, respectively); after surgery, the activity decreased (137 +/- 15 mU/g, p < 0.001) but not the levels of HL-mRNA (4.3-fold). Plasma HL activity was also high (4.31 +/- 0.94 mU/mL plasma), and it decreased during weight loss (2.01 +/- 0.29 mU/mL, p < 0.01); moreover, it correlated (r = 0.3694, p < 0.05) with decreased liver HL activity. Adrenocorticotropic hormone in MO was higher (27 +/- 3 pg/mL) than after surgery (13 +/- 1 pg/mL, p < 0.001). All hepatic and plasma lipids were significantly increased in MO patients, but, after bariatric surgery, most of those parameters recovered or normalized. Liver HL activity correlated with total and esterified cholesterol (r = 0.4399, p < 0.001 and r = 0.4395, p < 0.01, respectively).
conclusionHigh HL in MO patients could allow for liver intake of cholesterol that could be re-exported to steroidogenic organs to synthesize steroidal hormones. A decrease of plasma HL during weight loss could be a good index for improvement of liver disease.
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