ArticleObesity surgery2009
A rodent model of adjustable gastric band surgery-implications for the understanding of underlying mechanisms.
Article in Obesity surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma.Frontiers in oncology · 2021Review
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- Upper Gastrointestinal Function in Morbidly Obese Adolescents Before and 6 Months After Gastric Banding.Obesity surgery · 2018Observational
- Article
- Pre-operative weight loss does not predict weight loss following laparoscopic adjustable gastric banding.Obesity surgery · 2013Article
- Article
- Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.Annals of surgery · 2011Article
- Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.Obesity surgery · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBariatric surgery is currently the only anti-obesity therapy that can deliver weight loss of up to 20-30% of body weight. Laparoscopic adjustable gastric banding (LAGB) and Roux-en-y gastric bypass are the most commonly performed of these surgeries. The mechanisms by which LAGB initiates an increase in satiety remain completely unknown. The aim of this study is to establish a rodent model of adjustable gastric banding (AGB) that will enable investigation of these mechanisms.
methodsSprague-Dawley rats were implanted with adjustable gastric bands immediately below the gastro-esophageal junction around the glandular stomach. This band, as in humans, can be inflated via an exteriorized port resulting in an incremental impact on the stomach.
resultsRats with an incremental inflation of the AGB showed a clear stepwise reduction in food intake and body weight. Normal food intake and body weight gain were restored with band deflation. Barium-assisted X-ray of the stomach showed the formation of a small gastric pouch proximal to the inflated band in a manner analogous to the human LAGB.
conclusionsThis is the first animal model of the AGB that allows incremental inflation for optimal tightening of the band in the conscious animal with corresponding effects on food intake and body weight. This model will allow measurement of acute and chronic neural and hormonal changes following activation of the band in the conscious animal and will provide the potential to inform and improve surgical approaches that are at the forefront of obesity treatments.
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