ArticleImmunogenetics2008
KIR haplotypes defined by segregation analysis in 59 Centre d'Etude Polymorphisme Humain (CEPH) families.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis.BMC medical genetics · 2019Pooled it
- Variations in KIR genes: a study in HIV-1 serodiscordant couples.BioMed research international · 2014Trial
- Trial
- Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region.Molecular biology and evolution · 2022Article
- Haplotype-Based Analysis ofFrontiers in immunology · 2020Article
- Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation.Frontiers in immunology · 2019Review
- Novel multiplex PCR-SSP method for centromeric KIR allele discrimination.Scientific reports · 2018Article
- Genotypic diversity of the Killer Cell Immunoglobulin-like Receptors (KIR) and their HLA class I Ligands in a Saudi population.Genetics and molecular biology · 2016Article
- Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions.Genes and immunity · 2015Article
- Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3.PLoS neglected tropical diseases · 2014Article
- Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses.PloS one · 2014Article
- Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.Genome medicine · 2014Article
- Immunogenetics of HIV disease.Immunological reviews · 2013Review
- Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans.PloS one · 2013Article
- Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors.Genome research · 2012Article
- Activating killer-cell immunoglobulin-like receptors (KIR) and their cognate HLA ligands are significantly increased in autism.Brain, behavior, and immunity · 2012Article
- Review: Immunogenetics of human placentation.Placenta · 2012Review
- Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.PloS one · 2012Article
- Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples.The Journal of infectious diseases · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, particularly since the sequence of entire KIR haplotypes have become available. To determine the extent of KIR haplotypic variability among individuals of northern European descent, we genotyped 59 CEPH families for presence/absence of all KIR genes and performed limited allelic subtyping at several KIR loci. A total of 20 unique haplotypes differing in gene content were identified, the most common of which was the previously defined A haplotype (f = 0.52). Several unusual haplotypes that probably arose as a consequence of unequal crossing over events were also identified. Linkage disequilibrium (LD) analysis indicated strong negative and positive LD between several pairs of genes, values that may be useful in determining haplotypic structure when family data are not available. These data provide a resource to aid in the interpretation of disease association data involving individuals of European descent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.