Evidence map›Paper›PMID 18971485›Full record

ReviewEndocrine reviews2008

The metabolic syndrome.

Marc-Andre Cornier, Dana Dabelea, Teri L Hernandez, Rachel C Lindstrom, Amy J Steig, Nicole R Stob, Rachael E Van Pelt, Hong Wang, Robert H Eckel

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 874 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
874citing papers in PubMed, 12 pooled it
46.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

874 citing papers in PubMed, 12 syntheses or guidelines pooled it, 2,088 citations in OpenAlex.

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  6. Effect ofCurrent medicinal chemistry · 2025
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  8. Epidemiological and mechanistic links between PMFrontiers in endocrinology · 2025
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814 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marc-Andre CornierUniversity of Colorado Denver, Division of Endocrinology, Metabolism, and Diabetes, Mail Stop 8106, 12801 East 17 Avenue, Room 7103, Aurora, Colorado 80045, USA. marc.cornier@ucdenver.edu
Dana Dabelea
Teri L Hernandez
Rachel C Lindstrom
Amy J Steig
Nicole R Stob
Rachael E Van Pelt
Hong Wang
Robert H Eckel
University of Colorado Denver · US

Funding

Regional fat-re-accumulation following lipectomy in pre- and postmenopausal womenR01DK077992 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI VAN PELT, RACHAEL E · 2007 to 2011
$2.2M
NIDDK NIH HHS R01 DK077992
6 · The paper itself

Abstract

The "metabolic syndrome" (MetS) is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the clustering of abdominal obesity, insulin resistance, dyslipidemia, and elevated blood pressure and is associated with other comorbidities including the prothrombotic state, proinflammatory state, nonalcoholic fatty liver disease, and reproductive disorders. Because the MetS is a cluster of different conditions, and not a single disease, the development of multiple concurrent definitions has resulted. The prevalence of the MetS is increasing to epidemic proportions not only in the United States and the remainder of the urbanized world but also in developing nations. Most studies show that the MetS is associated with an approximate doubling of cardiovascular disease risk and a 5-fold increased risk for incident type 2 diabetes mellitus. Although it is unclear whether there is a unifying pathophysiological mechanism resulting in the MetS, abdominal adiposity and insulin resistance appear to be central to the MetS and its individual components. Lifestyle modification and weight loss should, therefore, be at the core of treating or preventing the MetS and its components. In addition, there is a general consensus that other cardiac risk factors should be aggressively managed in individuals with the MetS. Finally, in 2008 the MetS is an evolving concept that continues to be data driven and evidence based with revisions forthcoming.

Indexed as

Metabolic SyndromeAnimalsHumans

Identifiers

PMID18971485
PMCPMC5393149
OpenAlexW2148824946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.