ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 89 citations in OpenAlex.
- Cannabis in cancer: a review of therapeutic potential, clinical and preclinical status, and legislation.Archives of pharmacal research · 2026Review
- Predicting the Mechanism of Tiannanxing-shengjiang Drug Pair in Treating Pain Using Network Pharmacology and Molecular Docking Technology.Current computer-aided drug design · 2024Article
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- Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease.Haematologica · 2023Article
- Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs.Scientific reports · 2021Article
- Intrathecal administration of Resolvin D1 and E1 decreases hyperalgesia in mice with bone cancer pain: Involvement of endocannabinoid signaling.Prostaglandins & other lipid mediators · 2020Article
- Article
- Cannabinoids for fibromyalgia pain: a critical review of recent studies (2015-2019).Journal of cannabis research · 2020Review
- The Endocannabinoid System of Animals.Animals : an open access journal from MDPI · 2019Review
- Sensitization of nociceptors by prostaglandin EBlood · 2019Article
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- Cannabinoids and Pain: New Insights From Old Molecules.Frontiers in pharmacology · 2018Review
- Article
- Endocannabinoids as Guardians of Metastasis.International journal of molecular sciences · 2016Review
- Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy.Journal of neurophysiology · 2015Article
- JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy.Pharmacological research · 2014Article
- A lipid gate for the peripheral control of pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Review
- The neurobiology of cancer pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Cannabinoids as therapeutic agents in cancer: current status and future implications.Oncotarget · 2014Review
- Peripheral gating of pain signals by endogenous lipid mediators.Nature neuroscience · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Tumors in bone are associated with pain in humans. Data generated in a murine model of bone cancer pain suggest that a disturbance of local endocannabinoid signaling contributes to the pain. When tumors formed after injection of osteolytic fibrosarcoma cells into the calcaneus bone of mice, cutaneous mechanical hyperalgesia was associated with a decrease in the level of anandamide (AEA) in plantar paw skin ipsilateral to tumors. The decrease in AEA occurred in conjunction with increased degradation of AEA by fatty acid amide hydrolase (FAAH). Intraplantar injection of AEA reduced the hyperalgesia, and intraplantar injection of URB597, an inhibitor of FAAH, increased the local level of AEA and also reduced hyperalgesia. An increase in FAAH mRNA and enzyme activity in dorsal root ganglia (DRG) L3-L5 ipsilateral to the affected paw suggests DRG neurons contribute to the increased FAAH activity in skin in tumor-bearing mice. Importantly, the anti-hyperalgesic effects of AEA and URB597 were blocked by a CB1 receptor antagonist. Increased expression of CB1 receptors by DRG neurons ipsilateral to tumor-bearing limbs may contribute to the anti-hyperalgesic effect of elevated AEA levels. Furthermore, CB1 receptor protein-immunoreactivity as well as inhibitory effects of AEA and URB597 on the depolarization-evoked Ca(2+) transient were increased in small DRG neurons cocultured with fibrosarcoma cells indicating that fibrosarcoma cells are sufficient to evoke phenotypic changes in AEA signaling in DRG neurons. Together, the data provide evidence that manipulation of peripheral endocannabinoid signaling is a promising strategy for the management of bone cancer pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.