ArticleJournal of clinical microbiology2009
Phenotypic and genotypic analysis of enterotoxigenic Escherichia coli in samples obtained from Egyptian children presenting to referral hospitals.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Comparative prevalence of diarrheagenicThe Pan African medical journal · 2024Article
- The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates.mSphere · 2023Article
- Confronting challenges to enterotoxigenicFrontiers in tropical diseases · 2021Article
- Etiology and pathogenicity of bacterial isolates: a cross sectional study among diarrheal children below five years in central regions of Kenya.The Pan African medical journal · 2018Article
- Article
- Chaperone-Usher Pili Loci of Colonization Factor-Negative Human EnterotoxigenicFrontiers in cellular and infection microbiology · 2016Article
- Diarrhea burden due to natural infection with enterotoxigenic Escherichia coli in a birth cohort in a rural Egyptian community.Journal of clinical microbiology · 2014Article
- Pathogenicity and phenotypic characterization of enterotoxigenic Escherichia coli isolates from a birth cohort of children in rural Egypt.Journal of clinical microbiology · 2014Article
- Molecular characterization of Enterotoxigenic Escherichia coli strains isolated from diarrheal patients in Korea during 2003-2011.PloS one · 2014Article
- Molecular characterization of enterotoxigenic Escherichia coli isolates recovered from children with diarrhea during a 4-year period (2007 to 2010) in Bolivia.Journal of clinical microbiology · 2013Article
- Hotel clinic-based diarrheal and respiratory disease surveillance in U.S. service members participating in Operation Bright Star in Egypt, 2009.The American journal of tropical medicine and hygiene · 2012Article
- Molecular characterization of diarrheagenic Escherichia coli from Libya.The American journal of tropical medicine and hygiene · 2012Article
- Enteric disease surveillance under the AFHSC-GEIS: current efforts, landscape analysis and vision forward.BMC public health · 2011Review
- The prevalence of enterotoxigenic e. Coli isolated from the stools of children aged 0-10 years with diarrhea in mid-anatolia region, Turkey.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Genotypic and phenotypic characterization of enterotoxigenic Escherichia coli strains isolated from Peruvian children.Journal of clinical microbiology · 2010Article
- Antibody against recombinant heat labile enterotoxin B subunit (rLTB) could block LT binding to ganglioside M1 receptor.Iranian journal of microbiology · 2010Article
- Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins.Infection and immunity · 2010Article
- Detection of Escherichia coli enteropathogens by multiplex polymerase chain reaction from children's diarrheal stools in two Caribbean-Colombian cities.Foodborne pathogens and disease · 2010Article
- Enterotoxigenic Escherichia coli multilocus sequence types in Guatemala and Mexico.Emerging infectious diseases · 2010Article
- Development of multiplex PCR assays for detection of enterotoxigenic Escherichia coli colonization factors and toxins.Journal of clinical microbiology · 2009Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hospital surveillance was established in the Nile River Delta to increase the understanding of the epidemiology of diarrheal disease among Egyptian children. Between September 2000 and August 2003, samples obtained from children less than 5 years of age who had diarrhea and who were seeking hospital care were cultured for enteric bacteria. Colonies from each culture with a morphology typical of that of Escherichia coli were tested for the heat-labile (LT) and heat-stable (ST) toxins by a GM-1-specific enzyme-linked immunosorbent assay and colonization factor (CF) antigens by an immunodot blot assay. Enterotoxigenic E. coli (ETEC) isolates were recovered from 320/1,540 (20.7%) children, and ETEC isolates expressing a known CF were identified in 151/320 (47%) samples. ST CFA/I, ST CS6, ST CS14, and LT and ST CS5 plus CS6 represented 75% of the CFs expressed by ETEC isolates expressing a detectable CF. Year-to-year variability in the proportion of ETEC isolates that expressed a detectable CF was observed (e.g., the proportion that expressed CFA/I ranged from 10% in year 1 to 21% in year 3); however, the relative proportions of ETEC isolates expressing a CF were similar over the reporting period. The proportion of CF-positive ETEC isolates was higher among isolates that expressed ST. ETEC isolates expressing CS6 were isolated significantly less often (P < 0.001) than isolates expressing CFA/I in children less than 1 year of age. Macrorestriction profiling of CFA/I-expressing ETEC isolates by using the restriction enzyme XbaI and pulsed-field gel electrophoresis demonstrated a wide genetic diversity among the isolates that did not directly correlate with the virulence of the pathogen. The genome plasticity demonstrated in the ETEC isolates collected in this work suggests an additional challenge to the development of a globally effective vaccine for ETEC.
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