Evidence map›Paper›PMID 18971347›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008

A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.

Curt D Sigmund

Open access · greenAbstract readCommentEditorial
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Curt D Sigmund
University of Iowa · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSIONR01HL061446 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 1999 to 2013
$4.8M
Role of Enhancers Regulating Renin Gene ExpressionR37HL048058 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2006 to 2015
$4.3M
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL061446NHLBI NIH HHS R37 HL048058
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Polymorphism, GeneticPromoter Regions, GeneticAngiotensinogenAnimalsBlood PressureGenetic Predisposition to DiseaseHaplotypesHumansHypertensionMiceMice, TransgenicRNA, MessengerTranscription, GeneticAngiotensinogenRNA, Messenger

Identifiers

PMID18971347
PMCPMC3597228
OpenAlexW2110847062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.